Document Detail


Neutrophil but not eosinophil inflammation is related to the severity of a first acute epidemic bronchiolitis in young infants.
MedLine Citation:
PMID:  18093085     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Acute bronchiolitis is the main cause of emergency visits and hospitalizations in infants. Recent data suggest that neutrophil- and eosinophil-mediated inflammations were part of bronchiolitis pathophysiology. Apart from the defined risk factors, few was known on the underlying pathophysiology, which might point out the differences observed in the severity of the disease. The aim of this study was to assess whether the clinical severity of acute epidemic bronchiolitis in young infants might be related to a specific underlying inflammatory process. Total and differential cell counts, IL-8, eotaxin, eosinophil cationic protein (ECP) and albumin levels were assessed at the time of admission in bronchial secretions from 37 infants (median age 17 wk) with acute bronchiolitis. Outcome severity variables were: hypoxemia, Silverman score, tachypnea, feeding alteration, and duration of hospitalization. Neutrophils predominated, and eosinophils were present in 54% of the infants. IL-8 levels strongly correlated with ECP and albumin levels. Albumin levels were correlated with ECP and eotaxin levels. IL-8 levels were higher in infants with hypoxemia and inversely related with SaO(2) levels. IL-8 and albumin levels significantly rose with respiratory rate, and Silverman score. IL-8, albumin and ECP levels were significantly higher in infants hospitalized >/=7 days. Furthermore, IL-8 levels were correlated with the duration of hospitalization. Neither cell counts nor eotaxin levels were related to the severity criteria studied. This study suggests that IL-8-associated airway inflammation significantly contributed to the severity of acute epidemic bronchiolitis.
Authors:
Christophe Marguet; Nathalie Bocquel; Jacques Benichou; Jean Pierre Basuyau; Marie France Hellot; Laure Couderc; Eric Mallet; Bertrand Macé
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-12-18
Journal Detail:
Title:  Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology     Volume:  19     ISSN:  1399-3038     ISO Abbreviation:  Pediatr Allergy Immunol     Publication Date:  2008 Mar 
Date Detail:
Created Date:  2008-02-08     Completed Date:  2008-04-22     Revised Date:  2008-05-28    
Medline Journal Info:
Nlm Unique ID:  9106718     Medline TA:  Pediatr Allergy Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  157-65     Citation Subset:  IM    
Affiliation:
Pediatric Respiratory Disease Unit, Rouen University Hospital-Charles Nicolle, Rouen cedex, France. christophe.marguet@chu-rouen.fr
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Albumins / metabolism
Anoxia / etiology,  immunology
Biological Markers / metabolism
Bronchiolitis, Viral / complications,  epidemiology,  immunology*
Disease Outbreaks
Enzyme-Linked Immunosorbent Assay
Eosinophils / immunology*
Female
France / epidemiology
Humans
Infant
Inflammation / immunology*
Interleukin-8 / metabolism
Length of Stay / statistics & numerical data
Leukocyte Count
Male
Neutrophils / immunology*
Prospective Studies
Severity of Illness Index*
Sputum / immunology
Chemical
Reg. No./Substance:
0/Albumins; 0/Biological Markers; 0/Interleukin-8

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