Document Detail

Neutrophil apoptosis in preeclampsia, do steroids confound the relationship?
MedLine Citation:
PMID:  15327445     Owner:  NLM     Status:  MEDLINE    
AIM: To investigate the influence of maternal corticosteroid administration on neutrophil apoptosis in early onset preeclampsia. METHODS: We investigated five groups: early onset preeclampsia (EOPET, <34 weeks, n = 10); late-onset preeclampsia (LOPET, > or =34 weeks, n = 7); normotensive intrauterine growth restriction (nIUGR, n = 11); normal pregnancy (NPC, n = 22); and non-pregnancy (n = 10). We examined, by flow cytometry, spontaneous neutrophil apoptosis after 18 h culture (hypodiploid DNA, Annexin V binding, propidium iodide [PI] permeability). RESULTS: For the 10 women with EOPET exposed to betamethasone in the previous 48 h, we found that neutrophil apoptosis was not inappropriately inhibited, in contrast to our previous findings in women not thus exposed. Neither LOPET nor nIUGR differed from normal pregnancy. CONCLUSION: Betamethasone alters the rate of spontaneous neutrophil apoptosis in EOPET. The anti-inflammatory influence of betamethasone may explain some of the differences between our previous and present findings with respect to neutrophil apoptosis in EOPET. Corticosteroids ameliorate the course of antenatal and postnatal preeclampsia. These results may reflect the mechanisms that underlie the transient improvements seen with antenatal dexamethasone use.
Akiko Fuchisawa; Stephan van Eeden; Laura A Magee; Beth Whalen; Peter C K Leung; James A Russell; Keith R Walley; Peter von Dadelszen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The journal of obstetrics and gynaecology research     Volume:  30     ISSN:  1341-8076     ISO Abbreviation:  J. Obstet. Gynaecol. Res.     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-08-25     Completed Date:  2004-10-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9612761     Medline TA:  J Obstet Gynaecol Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  342-8     Citation Subset:  IM    
Department of Obstetrics and Gynaecology, University of British Columbia, Vancouver, British Columbia V6H 3N1, Canada.
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MeSH Terms
Annexin A5 / metabolism
Betamethasone / administration & dosage*
Case-Control Studies
Cell Membrane Permeability
Cells, Cultured
Fetal Growth Retardation / blood
Flow Cytometry
Gestational Age
Glucocorticoids / administration & dosage*
Neutrophils / metabolism,  pathology*
Pre-Eclampsia / blood*
Prospective Studies
Reg. No./Substance:
0/Annexin A5; 0/Glucocorticoids; 36015-30-2/Propidium; 378-44-9/Betamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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