Document Detail

Neutrophil alkaline phosphatase activity in the urinary neutrophils of a patient with chronic myelogenous leukemia.
MedLine Citation:
PMID:  1984687     Owner:  NLM     Status:  MEDLINE    
We report here a patient with Philadelphia chromosome (Ph)-positive chronic myelogenous leukemia (CML) in chronic phase in whom the alkaline phosphatase activity of neutrophils in the peripheral blood was low while at the same time the alkaline phosphatase content of neutrophils present in the urine was elevated. This observation provides independent clinical support for the recent experimental finding that an extrinsic factor (granulocyte colony-stimulating factor) controls alkaline phosphatase expression in human neutrophils.
G Janković; M Petrović; M Colović; M Zilić; R Dotlić
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  American journal of hematology     Volume:  36     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  1991 Jan 
Date Detail:
Created Date:  1991-01-25     Completed Date:  1991-01-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  67-8     Citation Subset:  IM    
Institute of Hematology, University Clinical Center, Faculty of Medicine, Belgrade, Yugoslavia.
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MeSH Terms
Alkaline Phosphatase / metabolism*
Blood Cells / enzymology*
Leukemia, Myelogenous, Chronic, BCR-ABL Positive / enzymology*
Neutrophils / enzymology*
Urine / cytology*
Reg. No./Substance:
EC Phosphatase

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