Document Detail

Neutrophil activation and morbidity in young adults with cyanotic congenital heart disease.
MedLine Citation:
PMID:  8180336     Owner:  NLM     Status:  MEDLINE    
Young adults with cyanotic congenital heart disease have a high incidence of respiratory and haemostatic problems. Activated neutrophils release vasoactive and chemotactic factors which result in endothelial injury, lung parenchymal damage and the activation of platelets and coagulation pathways. To investigate the contribution of neutrophil activation to morbidity in young adults with cyanotic congenital heart disease, plasma neutrophil elastase levels were measured in 25 cyanotic patients and the results compared to patients with acyanotic heart disease and normal controls. Neutrophil elastase levels were significantly elevated in the group with cyanotic congenital heart disease (P < 0.001). Platelet activation was significantly increased in the patients with cyanotic heart disease (P < 0.001). Platelet aggregation was impaired only in those with haematocrits greater than 0.50 (P < 0.02). Whole blood coagulation, as determined by thrombelastography, was within normal limits. The reason for neutrophil activation in patients with cyanotic congenital heart disease is unclear, but activated neutrophils may contribute to the respiratory and haemostatic problems common to these patients.
K A McLeod; P Martin; G Williams; D R Walker
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis     Volume:  5     ISSN:  0957-5235     ISO Abbreviation:  Blood Coagul. Fibrinolysis     Publication Date:  1994 Feb 
Date Detail:
Created Date:  1994-06-10     Completed Date:  1994-06-10     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9102551     Medline TA:  Blood Coagul Fibrinolysis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  17-22     Citation Subset:  IM    
Department of Cardiology, Killinbeck Hospital, Leeds, UK.
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MeSH Terms
Heart Defects, Congenital / blood*
Leukocyte Elastase
Middle Aged
Neutrophils / physiology*
Pancreatic Elastase / blood
Platelet Activation
Platelet Aggregation
Reg. No./Substance:
EC Elastase; EC Elastase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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