| Neutrophil-Derived Cathelicidin Promotes Adhesion of Classical Monocytes. | |
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MedLine Citation:
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PMID: 23283724 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Rationale: The leukocyte response in acute inflammation is characterized by an initial recruitment of neutrophils preceding a second wave of monocytes. Neutrophil-derived granule proteins were suggested to hold an important role in this cellular switch. The exact mechanisms by which neutrophils mediate these processes are only partially understood. Objective: To investigate the role of neutrophils and their granule contents in the adhesion of monocyte subpopulations in acute inflammation. Methods and Results: Here, we show that neutrophil-derived cathelicidins (human: LL37, mouse: CRAMP) induce adhesion of classical monocytes but not of non-classical monocytes in the mouse cremaster muscle and in in vitro flow chamber assays. CRAMP is released from emigrated neutrophils and then transported across the endothelium where it is presented to rolling leukocytes. Endothelial-bound cathelicidin activates FPR2 on classical monocytes, resulting in monocytic β1- and β2-integrin conformational change towards an extended, active conformation that allows for adhesion to their respective ligands VCAM-1 and ICAM-1. Conclusions: These data elucidate a novel mechanism of neutrophil-mediated monocyte recruitment, which could be targeted in conditions where recruitment of classical monocytes plays an unfavorable role. |
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Authors:
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Sarawuth Wantha; Jean-Eric Alard; Remco Ta Megens; Anne M van der Does; Yvonne Döring; Maik Drechsler; Christine T N Pham; Ming-Wei Wang; Ji-Min Wang; Richard Gallo; Philipp von Hundelshausen; Lennart Lindbom; Tilman M Hackeng; Christian Weber; Oliver Soehnlein |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-2 |
Journal Detail:
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Title: Circulation research Volume: - ISSN: 1524-4571 ISO Abbreviation: Circ. Res. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-3 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0047103 Medline TA: Circ Res Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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1Physiology and Pharmacology, LMU Munich, Pettenkoferstr. 9, Munich, N/A, 80336, GERMANY. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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