| Neutrophil Depletion Reduces Blood-Brain Barrier Breakdown, Axon Injury, and Inflammation After Intracerebral Hemorrhage. | |
| | |
MedLine Citation:
|
PMID: 21293296 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Neutrophils are thought to contribute to damage after intracerebral hemorrhage (ICH), but there is little direct evidence for this. We depletedcirculating blood neutrophils with an anti-polymorphonuclear leukocyte antibody (anti-PMN) before inducing ICH in the rat striatum. Neutrophil infiltration, which was mainly at the edge of the hematoma, was decreased by more than 60% by anti-PMN mediated depletion. We then analyzed neutrophil contributions to BBB breakdown, white matter damage (axons and myelin), and glial and inflammatory responses, both spatially and temporally. Neutrophil depletion reduced BBB leakiness inthe peri-hematoma region. Matrix metalloprotease 9, which is thought to contribute to BBB breakdown, was restricted to neutrophils after ICHand was thus reduced by neutrophil depletion. Early perihematomalaxonal injury seen at 1 and 3 days after ICH was decreased by depleting neutrophils, and at later times (7 and 14 days), the astrocytic and microglia/macrophage responses were reduced in the perihematoma region and the surrounding striatum. Detailed spatial analysis showed that neutrophil depletion reduced infiltration of activated microglia/macrophages in the peri-hematoma white matter tracts and decreased myelin fragmentation and axon damage. These results show that, in experimental ICH, neutrophils produce matrix metalloprotease9and contribute to blood vessel disruption, BBB breakdown, axon damage, and astrocytic and microglial/macrophage responses thatevolve after ICH. |
| | |
Authors:
|
Iska Moxon-Emre; Lyanne C Schlichter |
Related Documents
:
|
16877636 - Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced l... 16921366 - Cftr regulates phagosome acidification in macrophages and alters bactericidal activity. 12454786 - Effects of concurrent ozone exposure on the pathogenesis of cigarette smoke-induced emp... 3004226 - Crocidolite-induced pulmonary fibrosis in mice. cytokinetic and biochemical studies. 22065996 - A differential concentration-dependent effect of ivig on neutrophil functions: relevanc... 16877636 - Alveolar macrophages contribute to alveolar barrier dysfunction in ventilator-induced l... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-2 |
Journal Detail:
|
Title: Journal of neuropathology and experimental neurology Volume: - ISSN: 0022-3069 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-2-4 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 2985192R Medline TA: J Neuropathol Exp Neurol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
|
From the Toronto Western Research Institute, University Health Network; and Department of Physiology, University of Toronto, Toronto, Canada. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Neuronal-astrocyte metabolic interactions: understanding the transition into abnormal astrocytoma me...
Next Document: Hypoxia-Induced Cellular and Vascular Changes in the Nucleus Tractus Solitarius and Ventrolateral Me...