Document Detail

Neutrophil CD64 as a sepsis biomarker.
MedLine Citation:
PMID:  22420242     Owner:  NLM     Status:  MEDLINE    
Neutrophilic granulocytes express their Fcgamma receptor, also known as the CD64 antigen, predominantly when they are activated. This makes neutrophil CD64 a potential biomarker for infection and sepsis. Indeed there is ample literature on the diagnostic utility of neutrophil CD64 in a variety of diseases. This review summarizes the literature on its application as a sepsis biomarker, in adults as well as in neonates and infants. The available data indicate that neutrophil CD64 seems to have high sensitivity (86%) and specificity (87%), but the methodological quality of most studies is questionable. Nevertheless, neutrophil CD64 appears to be a better diagnostic test than traditional hematological assays, C-reactive protein and probably even procalcitonin. Application of neutrophil CD64 in other conditions than sepsis is briefly presented. Finally, future clinical studies are discussed which are needed in order to confirm the diagnostic performance of this promising biomarker.
Johannes J M L Hoffmann
Publication Detail:
Type:  Evaluation Studies; Journal Article; Review    
Journal Detail:
Title:  Biochemia medica     Volume:  21     ISSN:  1330-0962     ISO Abbreviation:  Biochem Med (Zagreb)     Publication Date:  2011  
Date Detail:
Created Date:  2012-03-16     Completed Date:  2012-04-09     Revised Date:  2013-07-31    
Medline Journal Info:
Nlm Unique ID:  9610305     Medline TA:  Biochem Med (Zagreb)     Country:  Croatia    
Other Details:
Languages:  eng     Pagination:  282-90     Citation Subset:  IM    
Abbott Diagnostics, Scientific Affairs Hematology, Wiesbaden-Delkenheim, Germany.
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MeSH Terms
Biological Markers* / analysis,  metabolism
Infant, Newborn
Neutrophils / metabolism*
Predictive Value of Tests
Receptors, IgG / analysis,  metabolism*,  physiology*
Sepsis / blood,  congenital,  diagnosis*
Severity of Illness Index
Reg. No./Substance:
0/Biological Markers; 0/Receptors, IgG

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