| Neutrophil CD64 as a sepsis biomarker. | |
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MedLine Citation:
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PMID: 22420242 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Neutrophilic granulocytes express their Fcgamma receptor, also known as the CD64 antigen, predominantly when they are activated. This makes neutrophil CD64 a potential biomarker for infection and sepsis. Indeed there is ample literature on the diagnostic utility of neutrophil CD64 in a variety of diseases. This review summarizes the literature on its application as a sepsis biomarker, in adults as well as in neonates and infants. The available data indicate that neutrophil CD64 seems to have high sensitivity (86%) and specificity (87%), but the methodological quality of most studies is questionable. Nevertheless, neutrophil CD64 appears to be a better diagnostic test than traditional hematological assays, C-reactive protein and probably even procalcitonin. Application of neutrophil CD64 in other conditions than sepsis is briefly presented. Finally, future clinical studies are discussed which are needed in order to confirm the diagnostic performance of this promising biomarker. |
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Authors:
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Johannes J M L Hoffmann |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biochemia medica : časopis Hrvatskoga društva medicinskih biokemičara / HDMB Volume: 21 ISSN: 1330-0962 ISO Abbreviation: Biochem Med (Zagreb) Publication Date: 2011 |
Date Detail:
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Created Date: 2012-03-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9610305 Medline TA: Biochem Med (Zagreb) Country: Croatia |
Other Details:
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Languages: eng Pagination: 282-90 Citation Subset: IM |
Affiliation:
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Abbott Diagnostics, Scientific Affairs Hematology, Wiesbaden-Delkenheim, Germany. hans.hoffmann@abbott.com |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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