| Neutrophil adsorption by polymyxin B-immobilized fiber column for acute exacerbation in patients with interstitial pneumonia: a pilot study. | |
| | |
MedLine Citation:
|
PMID: 20185904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND/AIMS: Polymyxin B-immobilized fiber (PMX) treatment has beneficial effects in patients with acute lung injury/acute respiratory distress syndrome or acute exacerbation of idiopathic pulmonary fibrosis. This study was aimed to clarify the mechanism of PMX treatment for acute exacerbation of interstitial pneumonia (IP). MATERIALS AND METHODS: Sixteen consecutive IP patients with acute exacerbation were included. The patients were treated with PMX once daily for 2 successive days at a flow rate of 80-100 ml/min for 6 h. Cells adsorbed by PMX were analyzed morphologically by electron microscopy. Surface markers of these cells were determined by flow cytometry. Serum matrix metalloproteinase (MMP)-9 was measured before and after PMX treatment. RESULTS: Cells adsorbed by PMX were neutrophils and highly expressed HLA-DR, CD14, CD62L and CD114. Serum MMP-9 levels were significantly decreased after PMX treatment. CONCLUSION: This pilot study demonstrated neutrophil adsorption by PMX and its possible clinical application for acute exacerbation of IP. |
| | |
Authors:
|
Shinji Abe; Yoshitsugu Seo; Hiroki Hayashi; Kuniko Matsuda; Jiro Usuki; Arata Azuma; Shoji Kudoh; Akihiko Gemma |
Related Documents
:
|
12387964 - Deficiency of antibacterial peptides in patients with morbus kostmann: an observation s... 21922874 - Assessment of cassava toxicity in patients with tropical chronic pancreatitis. 12695164 - Primary sjögren's syndrome associated agranulocytosis: a benign disorder? 7606944 - Leukotriene b4 in bronchoalveolar lavage fluid of patients with diffuse panbronchiolitis. 3174924 - Cryptococcal infection of the nervous system. 9930804 - Mr imaging for traumatic tears of the rotator cuff: high prevalence of greater tuberosi... |
Publication Detail:
|
Type: Journal Article Date: 2010-02-24 |
Journal Detail:
|
Title: Blood purification Volume: 29 ISSN: 1421-9735 ISO Abbreviation: Blood Purif. Publication Date: 2010 |
Date Detail:
|
Created Date: 2010-06-18 Completed Date: 2010-10-08 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8402040 Medline TA: Blood Purif Country: Switzerland |
Other Details:
|
Languages: eng Pagination: 321-6 Citation Subset: IM |
Copyright Information:
|
2010 S. Karger AG, Basel. |
Affiliation:
|
Department of Pulmonary Medicine/Infection and Oncology, Nippon Medical School, Tokyo, Japan. sabe@nms.ac.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Aged Cell Separation Cell Shape Female Flow Cytometry Hemoperfusion / methods* Humans Immunophenotyping Lung Diseases, Interstitial / pathology, therapy* Male Middle Aged Neutrophils / pathology* Observation / methods Pilot Projects Polymyxin B / therapeutic use* |
| Chemical | |
Reg. No./Substance:
|
1404-26-8/Polymyxin B |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Regional Body Composition of Indian Women from a Low-Income Group and Its Association with Anthropom...
Next Document: Effect of Extracellular ATP on Cisplatin-Induced Cytotoxicity in Human Ovarian Carcinoma Cells.