Document Detail


Neutropenia in the acute phase of Kawasaki disease and prevention of coronary artery aneurysm.
MedLine Citation:
PMID:  19674356     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: The significance of neutropenia in Kawasaki disease (KD) has not been fully elucidated as yet. METHODS: Subjects were retrospectively sampled from two clinical trials. These patients treated with aspirin alone (ASA) and PolyglobinN-Bayel (PolyN) given as i.v. immunoglobulin were categorized as ASA-early (n = 0), ASA-late (n = 8), PolyN-early (n = 18), or PolyN-late (n = 27) based on the therapy administered and the incidence of neutropenia before the 10th day of illness (DI) and after 11 DI. Data regarding the time of onset of neutropenia, and incidence of coronary artery lesion (CAL) formation were obtained. P < 0.05 was considered statistically significant. RESULTS: No patients in the ASA group exhibited neutropenia within 10 DI. The time of onset of neutropenia in the PolyN-early group was 8 +/- 1.3 DI. That in the PolyN-late group (19.8 +/- 8 DI) was earlier than in the ASA-late group (26.6 +/- 14 DI; P < 0.025). PolyN-early patients had a lower incidence of CAL formation than ASA-non patients (patients without neutropenia in the ASA group; P = 0.00019) and ASA-late patients (P = 0.04). That in the PolyN-early group tended to be lower than in the PolyN-late group (P < 0.1). CONCLUSION: Early neutropenia indicated that circulating neutrophils within 10 DI may play an indispensable role in the following sequence to CAL formation in KD.
Authors:
Zenshiro Onouchi; Kenji Hamaoka; Seiichiro Ozawa; Koichi Sakata; Nobuyuki Kiyosawa; Hisato Ito
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  51     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-08-13     Completed Date:  2009-12-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  448-52     Citation Subset:  IM    
Affiliation:
Department of Pediatric Cardiology and Nephrology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. onouchi@dojinkai.com
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MeSH Terms
Descriptor/Qualifier:
Anti-Inflammatory Agents, Non-Steroidal / therapeutic use
Aspirin / therapeutic use
Coronary Aneurysm / prevention & control*
Humans
Immunoglobulins, Intravenous / therapeutic use
Immunologic Factors / therapeutic use
Mucocutaneous Lymph Node Syndrome / complications*,  physiopathology
Neutropenia / etiology*
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents, Non-Steroidal; 0/Immunoglobulins, Intravenous; 0/Immunologic Factors; 50-78-2/Aspirin

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