Document Detail

Neutropenia associated with cefotaxime.
MedLine Citation:
PMID:  6313313     Owner:  NLM     Status:  MEDLINE    
Neutropenia is rarely associated with cephalosporins. We report a case of neutropenia associated with cefotaxime. A seven-year-old boy was admitted to the Chidoribashi Hospital with suspected septicemia. Cefotaxime 2 g/d was started. On day 18, neutropenia associated with cefotaxime was suspected. On day 22, the patient was transferred to Fukuoka Children's Hospital because of continuing neutropenia and eosinophilia. In Fukuoka Children's Hospital, bone marrow puncture revealed severe bone marrow depression. After one month, the patient was discharged. When we considered case reports of granulocytopenia, leukopenia, and agranulocytosis associated with cephalosporins, we found two types of leukopenia. One is the granulocytopenic type and the other is the neutropenic type. In diagnosing leukopenia due to cephalosporins, an increased percentage of eosinophils in white-blood-cell analysis is significant.
T Ohsawa; F Furukawa
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Drug intelligence & clinical pharmacy     Volume:  17     ISSN:  0012-6578     ISO Abbreviation:  Drug Intell Clin Pharm     Publication Date:  1983 Oct 
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0212457     Medline TA:  Drug Intell Clin Pharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  739-41     Citation Subset:  IM    
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MeSH Terms
Agranulocytosis / chemically induced*
Bone Marrow / pathology
Cefotaxime / adverse effects*
Neutropenia / chemically induced*,  pathology
Reg. No./Substance:

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