| Neutron RBE for induction of tumors with high lethality in Sprague-Dawley rats. | |
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MedLine Citation:
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PMID: 11023605 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effectiveness of fission neutrons is compared to that of gamma rays and X rays with regard to the induction of malignancies in male Sprague-Dawley rats. The analysis is based on autopsy results. It is focused on tumors that tend to be present in animals dying early, which is indicative of a high degree of lethality. The relative biological effectiveness (RBE) is deduced from a comparison of the cumulative hazard functions. Different nonparametric models-the constant relative risk model, a time shift model, and an acceleration model-are employed in the comparison, and the resulting values of RBE are seen to be substantially independent of the choice of model. The results are in good agreement with earlier studies of nonlethal lung tumors in the same series of experiments. At neutron doses of 20 to 60 mGy, the RBE of fission neutrons is about 50. |
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Authors:
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C Wolf; J Lafuma; R Masse; M Morin; A M Kellerer |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Radiation research Volume: 154 ISSN: 0033-7587 ISO Abbreviation: Radiat. Res. Publication Date: 2000 Oct |
Date Detail:
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Created Date: 2000-11-03 Completed Date: 2000-11-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401245 Medline TA: Radiat Res Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 412-20 Citation Subset: IM; S |
Affiliation:
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Radiobiological Institute, University of Munich, Schillerstrasse 42, D-80336 Munich, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Dose-Response Relationship, Radiation Gamma Rays / adverse effects Hemangiosarcoma / etiology Models, Biological Neoplasms, Radiation-Induced / etiology* Neutrons / adverse effects* Proportional Hazards Models Radiation Dosage Rats Rats, Sprague-Dawley Relative Biological Effectiveness Risk Survival Analysis Thyroid Neoplasms / etiology X-Rays / adverse effects |
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