Document Detail


Neutron RBE for induction of tumors with high lethality in Sprague-Dawley rats.
MedLine Citation:
PMID:  11023605     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effectiveness of fission neutrons is compared to that of gamma rays and X rays with regard to the induction of malignancies in male Sprague-Dawley rats. The analysis is based on autopsy results. It is focused on tumors that tend to be present in animals dying early, which is indicative of a high degree of lethality. The relative biological effectiveness (RBE) is deduced from a comparison of the cumulative hazard functions. Different nonparametric models-the constant relative risk model, a time shift model, and an acceleration model-are employed in the comparison, and the resulting values of RBE are seen to be substantially independent of the choice of model. The results are in good agreement with earlier studies of nonlethal lung tumors in the same series of experiments. At neutron doses of 20 to 60 mGy, the RBE of fission neutrons is about 50.
Authors:
C Wolf; J Lafuma; R Masse; M Morin; A M Kellerer
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Radiation research     Volume:  154     ISSN:  0033-7587     ISO Abbreviation:  Radiat. Res.     Publication Date:  2000 Oct 
Date Detail:
Created Date:  2000-11-03     Completed Date:  2000-11-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401245     Medline TA:  Radiat Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  412-20     Citation Subset:  IM; S    
Affiliation:
Radiobiological Institute, University of Munich, Schillerstrasse 42, D-80336 Munich, Germany.
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MeSH Terms
Descriptor/Qualifier:
Animals
Dose-Response Relationship, Radiation
Gamma Rays / adverse effects
Hemangiosarcoma / etiology
Models, Biological
Neoplasms, Radiation-Induced / etiology*
Neutrons / adverse effects*
Proportional Hazards Models
Radiation Dosage
Rats
Rats, Sprague-Dawley
Relative Biological Effectiveness
Risk
Survival Analysis
Thyroid Neoplasms / etiology
X-Rays / adverse effects

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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