| Neutralizing antibodies hamper IFNbeta bioactivity and treatment effect on MRI in patients with MS. | |
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MedLine Citation:
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PMID: 17101906 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We measured neutralizing antibodies (NABs) and the in vivo biologic response to interferon-beta on neopterin and beta(2)-microglobulin blood levels. All NAB-negative patients had an in vivo biologic response (full or partial), whereas all high-level positive patients had no response. High-level NAB patients had more MRI activity than NAB-negative patients (p = 0.031). Patients with a full response had less MRI activity than patients without biologic response (p = 0.032). |
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Authors:
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P Soelberg Sorensen; T Tscherning; H K Mathiesen; A R Langkilde; C Ross; M Ravnborg; K Bendtzen |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurology Volume: 67 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2006 Nov |
Date Detail:
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Created Date: 2006-11-14 Completed Date: 2006-12-26 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 1681-3 Citation Subset: AIM; IM |
Affiliation:
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Danish Multiple Sclerosis Research Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. pss@rh.dk |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Antibodies / blood* Brain / drug effects, immunology, pathology Disease Progression Drug Resistance / immunology* Female Humans Interferon-beta / antagonists & inhibitors*, immunology* Magnetic Resonance Imaging Male Middle Aged Multiple Sclerosis / blood, drug therapy*, immunology* Neopterin / blood, immunology Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antibodies; 670-65-5/Neopterin; 77238-31-4/Interferon-beta |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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