Document Detail


Neutralization of proteases from Bothrops snake venoms by the aqueous extract from Casearia sylvestris (Flacourtiaceae).
MedLine Citation:
PMID:  11600149     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Aqueous extract from Casearia sylvestris leaves, a typical plant from Brazilian open pastures, was able to neutralize the hemorrhagic activity caused by Bothrops asper, Bothrops jararacussu, Bothrops moojeni, Bothrops neuwiedi and Bothrops pirajai venoms. It also neutralized two hemorrhagic metalloproteinases from Bothrops asper venom. Proteolytic activity on casein induced by bothropic venoms and by isolated proteases, including Bn2 metalloproteinase from B. neuwiedi venom, was also inhibited by the C. sylvestris extract in different levels. The alpha-fibrinogen chain was partially protected against degradation caused by B. jararacussu venom, when this venom was incubated with C. sylvestris extract. We also observed that this extract partially increased the time of plasma coagulation caused by B. jararacussu, B. moojeni and B. neuwiedi venoms. C. sylvestris extract did not induce proteolysis in any substrate assayed.
Authors:
M H Borges; A M Soares; V M Rodrigues; F Oliveira; A M Fransheschi; A Rucavado; J R Giglio; M I Homsi-Brandeburgo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  39     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-10-15     Completed Date:  2001-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  England    
Other Details:
Languages:  eng     Pagination:  1863-9     Citation Subset:  IM    
Affiliation:
Departamento de Genética e Bioquímica, Universidade Federal de Uberlândia, UFU, 38400-902 Uberlândia, MG, Brazil. mhborges@mono.icb.ufmg.br
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MeSH Terms
Descriptor/Qualifier:
Animals
Bothrops / physiology*
Caseins / metabolism
Crotalid Venoms / antagonists & inhibitors*,  enzymology
Enzyme Inhibitors / pharmacology*
Fibrinogen / metabolism
Fibrinolysis / drug effects
Hemorrhage / pathology,  prevention & control
Metalloendopeptidases / antagonists & inhibitors*,  metabolism
Plant Extracts / pharmacology*
Skin Diseases / pathology,  prevention & control
Chemical
Reg. No./Substance:
0/Caseins; 0/Crotalid Venoms; 0/Enzyme Inhibitors; 0/Plant Extracts; 9001-32-5/Fibrinogen; EC 3.4.24.-/Metalloendopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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