Document Detail

Neutralization of proteases from Bothrops snake venoms by the aqueous extract from Casearia sylvestris (Flacourtiaceae).
MedLine Citation:
PMID:  11600149     Owner:  NLM     Status:  MEDLINE    
Aqueous extract from Casearia sylvestris leaves, a typical plant from Brazilian open pastures, was able to neutralize the hemorrhagic activity caused by Bothrops asper, Bothrops jararacussu, Bothrops moojeni, Bothrops neuwiedi and Bothrops pirajai venoms. It also neutralized two hemorrhagic metalloproteinases from Bothrops asper venom. Proteolytic activity on casein induced by bothropic venoms and by isolated proteases, including Bn2 metalloproteinase from B. neuwiedi venom, was also inhibited by the C. sylvestris extract in different levels. The alpha-fibrinogen chain was partially protected against degradation caused by B. jararacussu venom, when this venom was incubated with C. sylvestris extract. We also observed that this extract partially increased the time of plasma coagulation caused by B. jararacussu, B. moojeni and B. neuwiedi venoms. C. sylvestris extract did not induce proteolysis in any substrate assayed.
M H Borges; A M Soares; V M Rodrigues; F Oliveira; A M Fransheschi; A Rucavado; J R Giglio; M I Homsi-Brandeburgo
Related Documents :
9184839 - Purification of rabbit skeletal muscle proteoglycogen: studies on the glucosyltransfera...
21097449 - Pregnancy and reproduction in autoimmune rheumatic diseases.
10729359 - Cytochrome p450-dependent n-dealkylation of l-deprenyl in c57bl mouse liver microsomes:...
10687959 - Presence of uterine peroxidase activity in the rat early pregnancy.
261519 - Development of sucrase activity: effect of maternal hormonal status and fetal programmi...
3376149 - Inhibition of human lymphocyte transformation by the macrocyclic trichothecenes roridin...
17717619 - Symptoms and immunologic markers among vulcanization workers in rubber industries in so...
20883919 - Vulvar edema.
18958929 - Is there any link between severe pre-eclampsia and defined polymorphisms in leptin and ...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  39     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  2001 Dec 
Date Detail:
Created Date:  2001-10-15     Completed Date:  2001-12-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  England    
Other Details:
Languages:  eng     Pagination:  1863-9     Citation Subset:  IM    
Departamento de Genética e Bioquímica, Universidade Federal de Uberlândia, UFU, 38400-902 Uberlândia, MG, Brazil.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bothrops / physiology*
Caseins / metabolism
Crotalid Venoms / antagonists & inhibitors*,  enzymology
Enzyme Inhibitors / pharmacology*
Fibrinogen / metabolism
Fibrinolysis / drug effects
Hemorrhage / pathology,  prevention & control
Metalloendopeptidases / antagonists & inhibitors*,  metabolism
Plant Extracts / pharmacology*
Skin Diseases / pathology,  prevention & control
Reg. No./Substance:
0/Caseins; 0/Crotalid Venoms; 0/Enzyme Inhibitors; 0/Plant Extracts; 9001-32-5/Fibrinogen; EC 3.4.24.-/Metalloendopeptidases

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Study of paralytic shellfish poisoning toxin profile in shellfish from the Mediterranean shore of Mo...
Next Document:  The facilitatory actions of snake venom phospholipase A(2) neurotoxins at the neuromuscular junction...