Document Detail

Neutralization of pathophysiological manifestations of Russell's viper envenoming by antivenom raised against gamma-irradiated toxoid.
MedLine Citation:
PMID:  8456449     Owner:  NLM     Status:  MEDLINE    
Rabbits were immunized against gamma-irradiated (100 krads) Russell's viper venom toxoid adsorbed to aluminium phosphate gel. The antivenom (0.1 ml) neutralized 5 LD50, 8 minimum hemorrhagic doses (MHD) and 14 minimum necrotic doses (MND) of venom. The coagulant and protease activities of the viper venom were neutralized more effectively than phospholipase A activity, by the toxoid antivenom.
M Mandal; R N Hati; A K Hati
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Toxicon : official journal of the International Society on Toxinology     Volume:  31     ISSN:  0041-0101     ISO Abbreviation:  Toxicon     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-04-16     Completed Date:  1993-04-16     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1307333     Medline TA:  Toxicon     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  213-6     Citation Subset:  IM    
Department of Medical Entomology, Calcutta School of Tropical Medicine, India.
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MeSH Terms
Antivenins / therapeutic use*
Blood Coagulation / drug effects
Gamma Rays
Lethal Dose 50
Mice, Inbred BALB C
Phospholipases A / metabolism
Snake Bites / physiopathology,  therapy*
Viper Venoms / immunology*,  radiation effects,  toxicity
Reg. No./Substance:
0/Antivenins; 0/Viper Venoms; EC 3.1.1.-/Phospholipases A

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