Document Detail

Neutralization escape variants of human immunodeficiency virus type 1 are transmitted from mother to infant.
MedLine Citation:
PMID:  16378985     Owner:  NLM     Status:  MEDLINE    
Maternal passive immunity typically plays a critical role in protecting infants from new infections; however, the specific contribution of neutralizing antibodies in limiting mother-to-child transmission of human immunodeficiency virus type 1 is unclear. By examining cloned envelope variants from 12 transmission pairs, we found that vertically transmitted variants were more resistant to neutralization by maternal plasma than were maternal viral variants near the time of transmission. The vertically transmitted envelope variants were poorly neutralized by monoclonal antibodies b12 [corrected] 2G12, 2F5, and 4E10 individually or in combination. Despite the fact that the infant viruses were among the most neutralization resistant in the mother, they had relatively few glycosylation sites. Moreover, the transmitted variants elicited de novo neutralizing antibodies in the infants, indicating that they were not inherently difficult to neutralize. The neutralization resistance of vertically transmitted viruses is in contrast to the relative neutralization sensitivity of viruses sexually transmitted within discordant couples, suggesting that the antigenic properties of viruses that are favored for transmission may differ depending upon mode of transmission.
Xueling Wu; Adam B Parast; Barbra A Richardson; Ruth Nduati; Grace John-Stewart; Dorothy Mbori-Ngacha; Stephanie M J Rainwater; Julie Overbaugh
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of virology     Volume:  80     ISSN:  0022-538X     ISO Abbreviation:  J. Virol.     Publication Date:  2006 Jan 
Date Detail:
Created Date:  2005-12-27     Completed Date:  2006-01-27     Revised Date:  2013-06-07    
Medline Journal Info:
Nlm Unique ID:  0113724     Medline TA:  J Virol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  835-44     Citation Subset:  IM    
Division of Human Biology, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, WA 98109-1024, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/DQ208424;  DQ208425;  DQ208426;  DQ208427;  DQ208428;  DQ208429;  DQ208430;  DQ208431;  DQ208432;  DQ208433;  DQ208434;  DQ208435;  DQ208436;  DQ208437;  DQ208438;  DQ208439;  DQ208440;  DQ208441;  DQ208442;  DQ208443;  DQ208444;  DQ208445;  DQ208446;  DQ208447;  DQ208448;  DQ208449;  DQ208450;  DQ208451;  DQ208452;  DQ208453;  DQ208454;  DQ208455;  DQ208456;  DQ208457;  DQ208458;  DQ208459;  DQ208460;  DQ208461;  DQ208462;  DQ208463;  DQ208464;  DQ208465;  DQ208466;  DQ208467;  DQ208468;  DQ208469;  DQ208470;  DQ208471;  DQ208472;  DQ208473;  DQ208474;  DQ208475;  DQ208476;  DQ208477;  DQ208478;  DQ208479;  DQ208480;  DQ208481;  DQ208482;  DQ208483;  DQ208484;  DQ208485;  DQ208486;  DQ208487;  DQ208488;  DQ208489;  DQ208490;  DQ208491;  DQ208492;  DQ208493;  DQ208494;  DQ208495;  DQ208496;  DQ208497;  DQ208498;  DQ208499;  DQ208500;  DQ208501
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MeSH Terms
Antibodies, Monoclonal / immunology
Breast Feeding / adverse effects
HIV Antibodies / immunology
HIV Infections / etiology,  transmission*,  virology*
HIV-1 / drug effects,  genetics*,  immunology*
Immune Sera / immunology
Infant, Newborn
Infectious Disease Transmission, Vertical*
Molecular Sequence Data
Neutralization Tests
Species Specificity
Viral Envelope Proteins / genetics
Grant Support
Reg. No./Substance:
0/Antibodies, Monoclonal; 0/HIV Antibodies; 0/Immune Sera; 0/Viral Envelope Proteins
Erratum In:
J Virol. 2006 Mar;80(5):2585

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