Document Detail

Neutralization antibody responses induced by Japanese encephalitis virus vaccine.
MedLine Citation:
PMID:  7346039     Owner:  NLM     Status:  MEDLINE    
Single doses of Japanese encephalitis (JE) vaccine of the Nakayama strain were given to members of the staffs of a hospital and 99 paired-sera were obtained. Neutralization antibody titers of the sera were determined against the Nakayama strain and E-50 strain, isolated from wild Culex tritaeniorhynchus using clone C6/36 of Singh's Aedes albopictus mosquito cell culture. Post-vaccination sera showed a significant neutralizing antibody response against both the Nakayama and E-50 strain. The geometrical mean neutralization titers of post-vaccination sera against the Nakayama and E-50 strains were in the same order, although the geometrical mean neutralization titer against the Nakayama strain was the higher in pre-vaccination sera. The antibody responses against the Nakayama strain and E-50 strain were somewhat different in detail: 7 individuals with a pre-vaccination neutralization titers of less than 10 showed antibody responses to the Nakayama strain, whereas 3 individuals of the same group did not show any detectable response to the E-50 strain.
S Susilowati; Y Okuno; T Fukunaga; M Tadano; R F Juang; K Fukai
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biken journal     Volume:  24     ISSN:  0006-2324     ISO Abbreviation:  Biken J     Publication Date:  1981 Dec 
Date Detail:
Created Date:  1982-09-24     Completed Date:  1982-09-24     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0373117     Medline TA:  Biken J     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  137-45     Citation Subset:  IM    
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MeSH Terms
Antibody Formation*
Cross Reactions
Encephalitis Virus, Japanese / immunology*
Neutralization Tests
Species Specificity
Viral Vaccines / immunology*
Reg. No./Substance:
0/Viral Vaccines

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