| Neutralization of Bothrops alternatus regional venom pools and individual venoms by antivenom: A systematic comparison. | |
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MedLine Citation:
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PMID: 21549143 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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In this study we report that variation in lethality, hemorrhagic potency and procoagulation between individual samples of Bothrops alternatus venom from a single region, and variation between regional pools at the national level are comparable in range. Furthermore, the range of relative neutralization potencies of individual venoms within a region overlaps, and sometimes exceeds, the range of neutralization of regional venom pools throughout the country. Thus, the potency of neutralization of a national venom pool is poorly predictive of the potencies of neutralization of its constituent regional venom pools and, furthermore, the potency of neutralization of a regional venom pool is poorly predictive of the potencies of neutralization of its individual venom constituents. The efficiencies of neutralization of each of these effects (lethality, hemorrhage and procoagulation) were not significantly related to each other and did not correlate to the corresponding toxic potency of each venom or venom pool. Some implications of these findings are discussed in the context of the distinction between experimental quantitation of antivenom potency and the amount of antivenom that might be actually required to successfully treat two apparently comparable B. alternatus envenomations. |
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Authors:
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Adolfo Rafael de Roodt; Laura Cecilia Lanari; Vanessa Costa de Oliveira; Rodrigo Daniel Laskowicz; Roberto Pablo Stock |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-4-27 |
Journal Detail:
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Title: Toxicon : official journal of the International Society on Toxinology Volume: - ISSN: 1879-3150 ISO Abbreviation: - Publication Date: 2011 Apr |
Date Detail:
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Created Date: 2011-5-9 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1307333 Medline TA: Toxicon Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier Ltd. |
Affiliation:
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Laboratorio de Toxinopatología, Centro de Patología Experimental y Aplicada, Facultad de Medicina, Universidad de Buenos Aires, Uriburu 950, 5° Piso, Lab. 555 (1427) Buenos Aires, Argentina; Área Investigación y Desarrollo/Serpentario, Instituto Nacional de Producción de Biológicos, Administración Nacional de Laboratorios e Institutos de Salud, Ministerio de Salud de la Nación, Av. Vélez Sarsfield, 563 (1281) Buenos Aires, Argentina. |
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