Document Detail


Neutralising antibody responses to two doses of measles vaccine at 5 and 13 months of age in the United Kingdom.
MedLine Citation:
PMID:  10491877     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Fifty-three children born in the United Kingdom between April 1993 and July 1994 were given two doses of measles vaccine, at 5 and 13 months of age, and their neutralising antibody reports were studied to assess the feasibility of protecting infants (aged 1 to 11 months) in the event of an outbreak or who were due to travel abroad. Sixteen infants responded at 5 months, an additional 35 responded at 13 months and two did not respond. The responses were inversely related to the levels of maternal antibodies (p < 0.0001). Infants who responded at 5 months also produced higher responses at 13 months than those who did not respond initially (p = 0.0001). No serious side effects were encountered. These data suggest that measles vaccine protects 30% of infants at 5 months and that a second dose at 13 months results in almost universal seroconversion.
Authors:
B Ko; D Roberts; N Begg; M Rao; L Teare; B Cohen
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Communicable disease and public health / PHLS     Volume:  2     ISSN:  1462-1843     ISO Abbreviation:  Commun Dis Public Health     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-06     Completed Date:  1999-10-06     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9808711     Medline TA:  Commun Dis Public Health     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  203-6     Citation Subset:  IM    
Affiliation:
Department of Community Paediatrics, Mid-Essex Health Authority, London. benko@northone.freeserve.co.uk
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Antibodies, Viral / blood*
Great Britain
Humans
Immunity, Maternally-Acquired / immunology
Infant
Measles Vaccine / administration & dosage,  adverse effects,  immunology*
Neutralization Tests
Chemical
Reg. No./Substance:
0/Antibodies, Viral; 0/Measles Vaccine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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