| Neutralising antibody responses to two doses of measles vaccine at 5 and 13 months of age in the United Kingdom. | |
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MedLine Citation:
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PMID: 10491877 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Fifty-three children born in the United Kingdom between April 1993 and July 1994 were given two doses of measles vaccine, at 5 and 13 months of age, and their neutralising antibody reports were studied to assess the feasibility of protecting infants (aged 1 to 11 months) in the event of an outbreak or who were due to travel abroad. Sixteen infants responded at 5 months, an additional 35 responded at 13 months and two did not respond. The responses were inversely related to the levels of maternal antibodies (p < 0.0001). Infants who responded at 5 months also produced higher responses at 13 months than those who did not respond initially (p = 0.0001). No serious side effects were encountered. These data suggest that measles vaccine protects 30% of infants at 5 months and that a second dose at 13 months results in almost universal seroconversion. |
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Authors:
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B Ko; D Roberts; N Begg; M Rao; L Teare; B Cohen |
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Publication Detail:
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Type: Clinical Trial; Journal Article |
Journal Detail:
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Title: Communicable disease and public health / PHLS Volume: 2 ISSN: 1462-1843 ISO Abbreviation: Commun Dis Public Health Publication Date: 1999 Sep |
Date Detail:
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Created Date: 1999-10-06 Completed Date: 1999-10-06 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9808711 Medline TA: Commun Dis Public Health Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 203-6 Citation Subset: IM |
Affiliation:
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Department of Community Paediatrics, Mid-Essex Health Authority, London. benko@northone.freeserve.co.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Antibodies, Viral / blood* Great Britain Humans Immunity, Maternally-Acquired / immunology Infant Measles Vaccine / administration & dosage, adverse effects, immunology* Neutralization Tests |
| Chemical | |
Reg. No./Substance:
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0/Antibodies, Viral; 0/Measles Vaccine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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