| Neutral endopeptidase inhibition: could it have a role in the treatment of female sexual arousal disorder? | |
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MedLine Citation:
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PMID: 20412067 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Female sexual arousal disorder (FSAD) is the inability to attain or maintain an adequate lubrication-swelling response of sexual excitement. The potentiation of vascular responses leading to increased blood flow in clitoris and vagina has represented the main focus in the pharmacological treatment of FSAD, including the evaluation of the type 5 phosphodiesterase (PDE5) inhibitors. However, due to a lack of clear efficacy, there is no approved pharmacotherapy for FSAD to date. In the present issue of the British Journal of Pharmacology, Wayman et al. show that the administration by intravenous or intravaginal routes of a novel neutral endopeptidase inhibitor, UK-414,445, results in enhanced genital blood flow responses to pelvic nerve stimulation in female rabbits, without significantly affecting blood pressure. Neutral endopeptidase inhibition, by preserving vasoactive peptides such as vasoactive intestinal polypeptide, raises the possibility of a new pharmacological approach to the treatment of FSAD. |
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Authors:
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Javier Angulo |
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Publication Detail:
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Type: Comment; Journal Article |
Journal Detail:
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Title: British journal of pharmacology Volume: 160 ISSN: 1476-5381 ISO Abbreviation: Br. J. Pharmacol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-04-23 Completed Date: 2010-07-26 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 7502536 Medline TA: Br J Pharmacol Country: England |
Other Details:
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Languages: eng Pagination: 48-50 Citation Subset: IM |
Affiliation:
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Departamento de Investigación, Hospital Universitario Ramón y Cajal, Madrid, Spain. javier.angulo@hrc.es |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Electric Stimulation Female Genitalia, Female / blood supply, drug effects*, innervation Neprilysin / antagonists & inhibitors, physiology* Pelvis / innervation Pentanoic Acids / pharmacology*, therapeutic use Rabbits Regional Blood Flow / drug effects Sexual Behavior, Animal / drug effects Sexual Dysfunctions, Psychological / drug therapy*, physiopathology Thiadiazoles / pharmacology*, therapeutic use Vasoactive Intestinal Peptide / physiology |
| Chemical | |
Reg. No./Substance:
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0/Pentanoic Acids; 0/Thiadiazoles; 0/UK-414,495; 37221-79-7/Vasoactive Intestinal Peptide; EC 3.4.24.11/Neprilysin |
| Comments/Corrections | |
Comment On:
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Br J Pharmacol. 2010 May;160(1):51-9
[PMID:
20412068
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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