Document Detail

Neutral amino acid transport during the cell cycle of cultured human lymphocytes.
MedLine Citation:
PMID:  7217224     Owner:  NLM     Status:  MEDLINE    
Neutral amino acid (isoleucine, leucine, and valine) transport was monitored in synchronous populations of WIL-2 cells, a diploid human lymphoblastoid B cell line. Cells were synchronized by either the double thymidine block technique or by density-dependent arrest in G1. Cells synchronized by these methods showed up to a 66% decrease in amino acid transport upon progressing from the early S phase through the G2 and M phases with a concomitant increase in transport during the G1 phase. The lowest activities of amino acid transport in synchronized cells were observed during the G2 and M phases.
M C Glassy; C E Furlong
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of cellular physiology     Volume:  107     ISSN:  0021-9541     ISO Abbreviation:  J. Cell. Physiol.     Publication Date:  1981 Apr 
Date Detail:
Created Date:  1981-06-13     Completed Date:  1981-06-13     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0050222     Medline TA:  J Cell Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  69-74     Citation Subset:  IM    
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MeSH Terms
Amino Acids, Branched-Chain / metabolism*
Biological Transport
Cell Cycle*
Cell Wall
Cells, Cultured
Isoleucine / metabolism
Leucine / metabolism
Lymphocytes / metabolism*
Valine / metabolism
Grant Support
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 61-90-5/Leucine; 7004-03-7/Valine; 73-32-5/Isoleucine

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