Document Detail

Neutral aminopeptidase and dipeptidyl peptidase IV activities in plasma of monosodium glutamate obese and food-deprived rats.
MedLine Citation:
PMID:  19876009     Owner:  NLM     Status:  MEDLINE    
Biometric parameters, glycemia and activity levels of plasma neutral aminopeptidase (APN) and dipeptidyl peptidase IV (DPPIV) were measured in monosodium glutamate obese and food-deprived rats (MSG-FD), to analyze the involvement of these enzymes in such situations. Plasma APN was distinguished as sensitive (PSA) (K(m) = 7.8 x 10(-5) mol/l) and predominantly insensitive (APM) (K(m) = 21.6 x 10(-5) mol/l) to puromycin, whereas DPPIV was sensitive (DPPIV-DS) (K(m) = 0.24 x 10(-5) mol/l) and predominantly insensitive (DPPIV-DI) (K(m) = 7.04 x 10(-5) mol/l) to diprotin A. Although unchanged in the MSG and food-deprived animals, APM activity levels were closely correlated with body mass, Lee index, and mass of retroperitoneal fat pad in the food deprived, but not in the MSG animals. DPPIV-DI activity levels decreased by 33% and were correlated with body mass, Lee index, and mass of periepididymal fat pad in the food-deprived MSG rats. These data suggest that APM and DPPIV-DI are respectively related to the downregulation of somatostatin in food-deprived rats, and to the recovery of energy balance in MSG obese rats during food deprivation.
Rafaela F Alponti; Paulo F Silveira
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2009-10-29
Journal Detail:
Title:  Obesity (Silver Spring, Md.)     Volume:  18     ISSN:  1930-739X     ISO Abbreviation:  Obesity (Silver Spring)     Publication Date:  2010 Jul 
Date Detail:
Created Date:  2010-06-28     Completed Date:  2010-09-29     Revised Date:  2012-08-13    
Medline Journal Info:
Nlm Unique ID:  101264860     Medline TA:  Obesity (Silver Spring)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1312-7     Citation Subset:  IM    
Laboratory of Pharmacology, Instituto Butantan, São Paulo, Brazil.
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MeSH Terms
2-Naphthylamine / analogs & derivatives,  metabolism,  pharmacology
Adipose Tissue / metabolism*
Antigens, CD13 / blood*
Blood Glucose / metabolism
Body Weight / physiology
Dipeptidyl Peptidase 4 / blood*
Enzyme Activation / drug effects,  physiology
Food Deprivation / physiology*
Hyperglycemia / metabolism
Obesity / metabolism*
Oligopeptides / pharmacology
Puromycin / pharmacology
Rats, Wistar
Sodium Glutamate / pharmacology*
Reg. No./Substance:
0/Blood Glucose; 0/Oligopeptides; 142-47-2/Sodium Glutamate; 2764-95-6/4-methoxy-2-naphthylamine; 53-79-2/Puromycin; 90614-48-5/diprotin A; 91-59-8/2-Naphthylamine; EC, CD13; EC Peptidase 4

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