Document Detail


Neurovestibular modulation of circadian and homeostatic regulation: vestibulohypothalamic connection?
MedLine Citation:
PMID:  12434016     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Chronic exposure to increased force environments (+G) has pronounced effects on the circadian and homeostatic regulation of body temperature (T(b)), ambulatory activity (Act), heart rate, feeding, and adiposity. By using the Brn 3.1 knockout mouse, which lacks vestibular hair cells, we recently described a major role of the vestibular system in mediating some of these adaptive responses. The present study used the C57BL6JEi-het mouse strain (het), which lacks macular otoconia, to elucidate the contribution of specific vestibular receptors. In this study, eight het and eight WT mice were exposed to 2G for 8 weeks by means of chronic centrifugation. In addition, eight het and eight WT mice were maintained as 1G controls in similar conditions. Upon 2G exposure, the WT exhibited a decrease in T(b) and an attenuated T(b) circadian rhythm. Act means and rhythms also were attenuated. Body mass and food intake were significantly lower than the 1G controls. After 8 weeks, percent body fat was significantly lower in the WT mice (P < 0.0001). In contrast, the het mice did not exhibit a decrease in mean T(b) and only a slight decrease in T(b) circadian amplitude. het Act levels were attenuated similarly to the WT mice. Body mass and food intake were only slightly attenuated in the het mice, and percent body fat, after 8 weeks, was not different in the 2G het group. These results link the vestibular macular receptors with specific alterations in homeostatic and circadian regulation.
Authors:
Patrick M Fuller; Timothy A Jones; Sherri M Jones; Charles A Fuller
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.     Date:  2002-11-14
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  99     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-27     Completed Date:  2003-01-14     Revised Date:  2013-06-09    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  15723-8     Citation Subset:  IM; S    
Affiliation:
Section of Neurobiology, Physiology and Behavior, University of California, Davis 95616, USA. cafuller@ucdavis.edu
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MeSH Terms
Descriptor/Qualifier:
Acceleration*
Adipose Tissue
Animals
Body Composition
Body Temperature Regulation
Body Weight
Centrifugation
Circadian Rhythm / physiology*
Feeding Behavior
Hair Cells, Vestibular / abnormalities,  physiology*
Heart Rate
Homeostasis / physiology*
Hypergravity*
Hypothalamus / physiology*
Locomotion
Male
Mice
Mice, Inbred C57BL
Mice, Knockout
Mice, Mutant Strains
Saccule and Utricle / abnormalities
Space Simulation
Telemetry
Vestibule, Labyrinth / abnormalities,  physiology*
Grant Support
ID/Acronym/Agency:
R01DC04477/DC/NIDCD NIH HHS
Investigator
Investigator/Affiliation:
T A Jones / U MO, Columbia; C A Fuller / U CA, Davis
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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