| Neurovascular coupling is impaired in slow walkers: The MOBILIZE Boston Study. | |
| | |
MedLine Citation:
|
PMID: 21674588 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
OBJECTIVE: Neurovascular coupling may be involved in compensatory mechanisms responsible for preservation of gait speed in elderly people with cerebrovascular disease. Our study examines the association between neurovascular coupling in the middle cerebral artery and gait speed in elderly individuals with impaired cerebral vasoreactivity. METHODS: Twenty-two fast and 20 slow walkers in the lowest quartile of cerebral vasoreactivity were recruited from the MOBILIZE Boston Study. Neurovascular coupling was assessed in bilateral middle cerebral arteries by measuring cerebral blood flow during the N-Back task. Cerebral white matter hyperintensities were measured for each group using magnetic resonance imaging. RESULTS: Neurovascular coupling was attenuated in slow compared to fast walkers (2.8%; 95% confidence interval [CI], -0.9 to 6.6 vs 8.2%; 95% CI, 4.7-11.8; p = 0.02). The odds ratio of being a slow walker was 6.4 (95% CI, 1.7-24.9; p = 0.007) if there was a high burden of white matter hyperintensity; however, this risk increased to 14.5 (95% CI, 2.3-91.1; p = 0.004) if neurovascular coupling was also attenuated. INTERPRETATION: Our results suggest that intact neurovascular coupling may help preserve mobility in elderly people with cerebral microvascular disease. Ann Neurol 2011; |
| | |
Authors:
|
Farzaneh A Sorond; Dan K Kiely; Andrew Galica; Nicola Moscufo; Jorge M Serrador; Ike Iloputaife; Svetlana Egorova; Elisa Dell'oglio; Dominik S Meier; Elizabeth Newton; William P Milberg; Charles R G Guttmann; Lewis A Lipsitz |
Related Documents
:
|
7955678 - Blood flow in chronic achilles tendinopathy. 6732668 - Observations on the use of glyceryl guaiacolate as an adjunct to general anaesthesia in... 3948858 - Physiological modifications of local haemodynamic conditions during bilateral isometric... 3585438 - Noninvasive monitoring of oxygenation during one-lung ventilation: a comparison of tran... 3810718 - Autoregulation of spinal cord blood flow: is the cord a microcosm of the brain? 12913088 - Fractal properties of perfusion heterogeneity in optimized arterial trees: a model study. |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-3-28 |
Journal Detail:
|
Title: Annals of neurology Volume: - ISSN: 1531-8249 ISO Abbreviation: - Publication Date: 2011 Mar |
Date Detail:
|
Created Date: 2011-6-15 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 7707449 Medline TA: Ann Neurol Country: - |
Other Details:
|
Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
|
Copyright © 2011 American Neurological Association. |
Affiliation:
|
Department of Neurology, Stroke Division, Brigham and Women's Hospital, Women's Hospital, Boston, MA; Harvard Medical School,; Institute for Aging Research, Hebrew SeniorLife, and. fsorond@partners.org. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Genetic inhibition of caspase-2 reduces hypoxic-ischemic and excitotoxic neonatal brain injury.
Next Document: Japanese macaque encephalomyelitis: A spontaneous multiple sclerosis-like disease in a nonhuman prim...