Document Detail


Neurovascular contact and blood pressure response in young, healthy, normotensive men.
MedLine Citation:
PMID:  11863246     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Neurovascular contact (NVC) of the left rostral ventrolateral medulla has been implicated in the pathogenesis of "essential" hypertension, and recent studies suggest that this anomaly may be genetically determined. We therefore assessed the prevalence of this vascular anomaly in young normotensive volunteers. We also studied blood pressure, heart rate reactivity, and changes in baroreflex sensitivity in response to mental and physical stress in a subset of subjects with positive and negative brainstem findings. METHODS: Magnetic resonance imaging of the brainstem was performed in 113 young (aged 25 +/- 8 years), normotensive male volunteers. Baroreflex sensitivity was then assessed in 13 subjects with positive brainstem findings and 20 subjects with negative findings. RESULTS: Left-sided NVC was found in 19 subjects. Blood pressure levels, heart rate, and baroreflex sensitivity were similar in all groups. However, modulation of baroreflex sensitivity was reduced under mental and physical stress in subjects with a positive finding for NVC. Subjects with a positive finding also had a significantly lower body mass index than those with a negative finding. CONCLUSIONS: Left-sided NVC is present in approximately one-fifth of young normotensive men, and may modulate the baroreceptor reflex under stress in these individuals.
Authors:
Henriette Hohenbleicher; Stephan Albert Schmitz; Hans-Christian Koennecke; Jens Offermann; Ralf Offermann; Karl-Jürgen Wolf; Armin Distler; Arya M Sharma
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  American journal of hypertension     Volume:  15     ISSN:  0895-7061     ISO Abbreviation:  Am. J. Hypertens.     Publication Date:  2002 Feb 
Date Detail:
Created Date:  2002-02-26     Completed Date:  2002-08-14     Revised Date:  2009-02-24    
Medline Journal Info:
Nlm Unique ID:  8803676     Medline TA:  Am J Hypertens     Country:  United States    
Other Details:
Languages:  eng     Pagination:  119-24     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Division of Endocrinology and Nephrology, Universitätsklinikum Benjamin Franklin, Berlin, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aging / physiology*
Baroreflex
Blood Pressure / physiology*
Brain Stem / blood supply*
Cerebrovascular Circulation / physiology*
Glossopharyngeal Nerve*
Heart Rate
Humans
Magnetic Resonance Imaging
Male
Nerve Compression Syndromes / diagnosis,  epidemiology*
Prevalence
Reference Values
Stress, Physiological / physiopathology
Stress, Psychological / physiopathology
Vagus Nerve*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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