Document Detail

Neurotropic melanoma invading the inferior alveolar nerve.
MedLine Citation:
PMID:  16021159     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Desmoplastic neurotropic melanoma (DNM) and neurotropic melanoma (NM), rare lesions of the head and neck, often present as a benign-appearing nodule which later progresses to cranial nerve involvement. OBJECTIVE: To discuss treatment and outcome of 3 cases of DNM/NM of the lower lip. METHODS: Three case reports with 12- to 54-month follow-up and literature review. RESULTS: The first case had an initial excision of melanoma of his lower lip and presented 16 years later with severe bilateral atrophy of his muscles of mastication with NM and underwent intensity modulated radiation therapy but no further resection. We also report two other cases of DNM of the lip, one of which received gamma knife radiosurgery for intracranial extension. LIMITATIONS: Small retrospective case series. CONCLUSIONS: Locoregional recurrences from DNM are more common than distant metastasis warranting vigilant surveillance following resection of the initial lesion. Radiation therapy and gamma knife radiosurgery may be used for cases of unresectable recurrences.
Doris Lin; Mohammed Kashani-Sabet; Timothy McCalmont; Mark I Singer
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of the American Academy of Dermatology     Volume:  53     ISSN:  1097-6787     ISO Abbreviation:  J. Am. Acad. Dermatol.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-07-15     Completed Date:  2005-11-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7907132     Medline TA:  J Am Acad Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S120-2     Citation Subset:  IM    
Department of Otolaryngology-Head and Neck Surgery, University of California, San Francisco, California 94143-0342, USA.
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MeSH Terms
Cranial Nerve Neoplasms / secondary*
Lip Neoplasms / pathology*,  surgery
Mandibular Nerve*
Melanoma / pathology*,  secondary,  surgery
Middle Aged
Neoplasm Invasiveness
Neoplasm Recurrence, Local*
Skin Neoplasms / pathology*,  surgery

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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