Document Detail

Neurotrophins and their receptors in the rat pituitary gland: regulation of BDNF and trkB mRNA levels by adrenal hormones.
MedLine Citation:
PMID:  7898323     Owner:  NLM     Status:  MEDLINE    
We studied the expression of messenger ribonucleic acids (mRNAs) for neurotrophins and neurotrophin receptors in the rat pituitary gland and examined the influence of adrenal hormones on their mRNA levels, using in situ hybridization and Northern blot analysis. The only neurotrophin present at detectable levels in the pituitary was brain-derived neurotrophic factor (BDNF), which was observed in the anterior and intermediate lobes. Several transcripts of the putative receptor for BDNF, trkB, were present in the anterior and posterior lobes of the pituitary. A low amount of trkC mRNA was found in both the anterior and the intermediate lobe. Dexamethasone treatment decreased both BDNF and trkB mRNA levels in the anterior lobe of the pituitary. Adrenalectomy had no effect on trkB expression, but it decreased BDNF mRNA levels in comparison to the control animals. This effect could not be reversed by dexamethasone substitution, suggesting that BDNF, mRNA levels may be regulated not only by glucocorticoids but also by other adrenal hormones. These results demonstrate that BDNF, trkB and trkC are expressed in the pituitary gland and that glucocorticoids and possibly other adrenal hormones may modulate pituitary functions by regulating the expression of neurotrophic factors and their receptors. Whether BDNF acts as a secreted hormone, a trophic factor, or has autocrine/paracrine functions within the pituitary through its receptor, trkB, remains to be studied.
J Kononen; S Soinila; H Persson; J Honkaniemi; T Hökfelt; M Pelto-Huikko
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Brain research. Molecular brain research     Volume:  27     ISSN:  0169-328X     ISO Abbreviation:  Brain Res. Mol. Brain Res.     Publication Date:  1994 Dec 
Date Detail:
Created Date:  1995-04-25     Completed Date:  1995-04-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8908640     Medline TA:  Brain Res Mol Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  347-54     Citation Subset:  IM    
Department of Biomedical Sciences, University of Tampere, Finland.
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MeSH Terms
Cerebral Cortex
Gene Expression
Glucocorticoids / metabolism*
In Situ Hybridization
Pituitary Gland / metabolism,  physiology*
RNA, Messenger
Rats, Sprague-Dawley
Receptors, Nerve Growth Factor / genetics*,  physiology
Reg. No./Substance:
0/Glucocorticoids; 0/RNA, Messenger; 0/Receptors, Nerve Growth Factor

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