| Neurotrophins: are they meaningful in chronic spontaneous urticaria? | |
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MedLine Citation:
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PMID: 19054925 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma neurotrophin levels are elevated in patients with allergic and autoimmune diseases. The present study was designed to investigate the serum neurotrophin levels in 42 patients displaying chronic spontaneous urticaria, as well as 22 healthy control subjects. Blood samples were obtained from subjects during their first visit to the clinic, and then again after one month of desloratadine therapy. No significant difference was found between patient and control groups in terms of basal serum neurotrophin levels. However, basal nerve growth factor levels in patients whose symptoms persisted despite treatment were significantly lower than those of the drug-responsive patients and the control group. In treatment-responsive patients, nerve growth factor increased after suppression of the symptoms. Our study suggests that chronic spontaneous urticaria is linked with changes serum nerve growth factor levels, and that the deregulation of neurotrophins may contribute to urticaria pathophysiology. |
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Authors:
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Ferhan Ozseker; Suna Büyüköztürk; Asli Gelincik; Bilge Depboylu; Sema Genç; Murat Giriş; Hacer Eroğlu; Sacide Erden; Bahattin Colakoğlu; Murat Dal; Aytuğ Akkor |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Asian Pacific journal of allergy and immunology / launched by the Allergy and Immunology Society of Thailand Volume: 26 ISSN: 0125-877X ISO Abbreviation: Asian Pac. J. Allergy Immunol. Publication Date: 2008 Jun-Sep |
Date Detail:
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Created Date: 2008-12-05 Completed Date: 2009-02-06 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8402034 Medline TA: Asian Pac J Allergy Immunol Country: Thailand |
Other Details:
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Languages: eng Pagination: 83-8 Citation Subset: IM |
Affiliation:
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Allergy Division, Department of Internal Medicine, Faculty of Medicine, Istanbul University, Istanbul, Turkey. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Brain-Derived Neurotrophic Factor / blood* Chronic Disease Drug Resistance Female Gene Expression Regulation Histamine H1 Antagonists, Non-Sedating / administration & dosage Histamine Release / drug effects Humans Loratadine / administration & dosage, analogs & derivatives Male Middle Aged Nerve Growth Factor / blood* Neuroimmunomodulation Neurotrophin 3 / blood* Severity of Illness Index Signal Transduction Urticaria / blood*, drug therapy, immunology |
| Chemical | |
Reg. No./Substance:
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0/Brain-Derived Neurotrophic Factor; 0/Histamine H1 Antagonists, Non-Sedating; 0/Neurotrophin 3; 0/desloratadine; 79794-75-5/Loratadine; 9061-61-4/Nerve Growth Factor |
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