| Neurotrophin-mediated neuroprotection by solid fetal telencephalic graft in middle cerebral artery occlusion: a preventive approach. | |
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MedLine Citation:
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PMID: 9820736 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In the present study, embryonic rat neocortex was implanted into the parietal subcortical area of adult naive animals. On the 7th day, the middle cerebral artery was permanently occluded ipsilateral to the graft. Twenty-four hours after middle cerebral artery occlusion, the extent of infarct was visualized by means of 2,3,5-triphenyltetrazolium chloride histochemistry and quantified in four different standardized coronal plains. Subsequently, the effects of fetal tissue grafting and those of transplantation were identified by using glial fibrillary acidic protein and nerve growth factor immunocytochemistry. The grafts integrated well into their new environment and significantly reduced the size of infarct in middle cerebral artery-occluded animals compared with both sham-operated and control rats 24 h postoperation. The underlying mechanism of this phenomenon might be an increased neurotrophic, particularly nerve growth factor, release by the grafted fetal tissue. Moreover, reactive astroglial cells may also trigger the neuroprotection by additional ischemia-induced nerve growth factor release. The present data demonstrate the potential neurotrophin-mediated protective effects of fetal brain tissue implanted into the adult rat brain before unilateral middle cerebral artery occlusion and the beneficial effects of astrocyte activation. |
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Authors:
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T Hortobágyi; T Harkany; R Reisch; R Urbanics; M Kálmán; C Nyakas; Z Nagy |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Brain research bulletin Volume: 47 ISSN: 0361-9230 ISO Abbreviation: Brain Res. Bull. Publication Date: 1998 Sep |
Date Detail:
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Created Date: 1999-01-22 Completed Date: 1999-01-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7605818 Medline TA: Brain Res Bull Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 185-91 Citation Subset: IM |
Affiliation:
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National Stroke Center, National Institute of Psychiatry and Neurology, Budapest, Hungary. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arterial Occlusive Diseases / surgery* Brain / pathology, physiopathology, surgery* Cerebral Arteries* Cerebral Infarction / pathology Fetal Tissue Transplantation* Male Nerve Growth Factors / physiology* Rats Rats, Long-Evans Telencephalon / embryology*, physiopathology |
| Chemical | |
Reg. No./Substance:
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0/Nerve Growth Factors |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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