Document Detail


Neurotrophin levels and behaviour in BALB/c mice: impact of intermittent exposure to individual housing and wheel running.
MedLine Citation:
PMID:  16343654     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study assessed the effects of intermittent individual housing on behaviour and brain neurotrophins, and whether physical exercise could influence alternate individual-housing-induced effects. Five-week-old BALB/c mice were either housed in enhanced social (E) or standard social (S) housing conditions for 2 weeks. Thereafter they were divided into six groups and for 6 weeks remained in the following experimental conditions: Control groups remained in their respective housing conditions (E-control, S-control); enhanced individual (E-individual) and standard individual (S-individual) groups were exposed every other day to individual cages without running-wheels; enhanced running-wheel (E-wheel) and standard running-wheel (S-wheel) groups were put on alternate days in individual running-wheel cages. Animals were assessed for activity in an automated individual cage system (LABORAS) and brain neurotrophins analysed. Intermittent individual housing increased behavioural activity and reduced nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) levels in frontal cortex; while it increased BDNF level in the amygdala and BDNF protein and mRNA in hippocampus. Besides normalizing motor activity and regulating BDNF and NGF levels in hippocampus, amygdala and cerebellum, physical exercise did not attenuate reduction of cortical NGF and BDNF induced by intermittent individual housing. This study demonstrates that alternate individual housing has significant impact on behaviour and brain neurotrophin levels in mice, which can be partially altered by voluntary physical exercise. Our results also suggest that some changes in neurotrophin levels induced by intermittent individual housing are not similar to those caused by continuous individual housing.
Authors:
Shun-Wei Zhu; Therese M Pham; Elin Aberg; Stefan Brené; Bengt Winblad; Abdul H Mohammed; Vera Baumans
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2005-12-15
Journal Detail:
Title:  Behavioural brain research     Volume:  167     ISSN:  0166-4328     ISO Abbreviation:  Behav. Brain Res.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-01-17     Completed Date:  2006-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8004872     Medline TA:  Behav Brain Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  1-8     Citation Subset:  IM    
Affiliation:
Division of Experimental Geriatrics, Department of NEUROTEC, Karolinska University Hospital, Karolinska Institute, Stockholm 141 86, Sweden. shunwei.zhu@neurotec.ki.se
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MeSH Terms
Descriptor/Qualifier:
Analysis of Variance
Animals
Behavior, Animal / physiology*
Brain / anatomy & histology,  metabolism*
Brain-Derived Neurotrophic Factor / genetics,  metabolism
Enzyme-Linked Immunosorbent Assay / methods
In Situ Hybridization / methods
Locomotion / physiology
Male
Mice
Mice, Inbred BALB C
Nerve Growth Factor / genetics,  metabolism
Nerve Growth Factors / genetics,  metabolism*
Physical Conditioning, Animal / physiology*
Running / physiology
Social Isolation*
Chemical
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Nerve Growth Factors; 9061-61-4/Nerve Growth Factor

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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