Document Detail


Neurotrophin-4/5 is implicated in the enhancement of axon regeneration produced by treadmill training following peripheral nerve injury.
MedLine Citation:
PMID:  21623957     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of neurotrophin-4/5 (NT-4/5) in the enhancement of axon regeneration in peripheral nerves produced by treadmill training was studied in mice. Common fibular nerves of animals of the H strain of thy-1-YFP mice, in which a subset of axons in peripheral nerves is marked by the presence of yellow fluorescent protein, were cut and surgically repaired using nerve grafts from non-fluorescent mice. Lengths of profiles of fluorescent regenerating axons were measured using optical sections made through whole mounts of harvested nerves. Measurements from mice that had undergone 1 h of daily treadmill training at modest speed (10 m/min) were compared with those of untrained (control) mice. Modest treadmill training resulted in fluorescent axon profiles that were nearly twice as long as controls at 1, 2 and 4 week survival times. Similar enhanced regeneration was found when cut nerves of wild type mice were repaired with grafts from NT-4/5 knockout mice or grafts made acellular by repeated freezing/thawing. No enhancement was produced by treadmill training in NT-4/5 knockout mice, irrespective of the nature of the graft used to repair the cut nerve. Much as had been observed previously for the effects of brief electrical stimulation, the effects of treadmill training on axon regeneration in cut peripheral nerves are independent of changes produced in the distal segment of the cut nerve and depend on the promotion of axon regeneration by changes in NT-4/5 expression by cells in the proximal nerve segment.
Authors:
Arthur W English; Delia Cucoranu; Amanda Mulligan; José A Rodriguez; Manning J Sabatier
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2011-05-30
Journal Detail:
Title:  The European journal of neuroscience     Volume:  33     ISSN:  1460-9568     ISO Abbreviation:  Eur. J. Neurosci.     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-20     Completed Date:  2011-10-24     Revised Date:  2014-09-21    
Medline Journal Info:
Nlm Unique ID:  8918110     Medline TA:  Eur J Neurosci     Country:  France    
Other Details:
Languages:  eng     Pagination:  2265-71     Citation Subset:  IM    
Copyright Information:
© 2011 The Authors. European Journal of Neuroscience © 2011 Federation of European Neuroscience Societies and Blackwell Publishing Ltd.
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / physiology*
Male
Mice
Mice, Knockout
Mice, Transgenic
Nerve Growth Factors / genetics,  physiology*
Nerve Regeneration / genetics,  physiology*
Peroneal Nerve / injuries,  physiology*,  transplantation
Physical Conditioning, Animal / physiology*
Transplants
Grant Support
ID/Acronym/Agency:
K12 GM000680/GM/NIGMS NIH HHS; K12 GM00680-05/GM/NIGMS NIH HHS; NS057190/NS/NINDS NIH HHS; R01 NS057190/NS/NINDS NIH HHS; R01 NS057190-01/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
0/Nerve Growth Factors; 143551-63-7/neurotrophin 4; 145172-44-7/neurotrophin 5
Comments/Corrections

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