Document Detail

Neurotrophin Levels in Cerebrospinal Fluid of Adult Patients with Meningitis and Encephalitis.
MedLine Citation:
PMID:  21358203     Owner:  NLM     Status:  Publisher    
Background: The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients. Methods: We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs. Results: Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p < 0.001 and p < 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase. Conclusion: Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection.
Madoka Kizawa-Ueda; Akihiro Ueda; Naoki Kawamura; Tomomasa Ishikawa; Eri Mutoh; Yu Fukuda; Ryouichi Shiroki; Kiyotaka Hoshinaga; Shinji Ito; Kunihiko Asakura; Tatsuro Mutoh
Related Documents :
10192423 - Molecular evolution of acute myeloid leukaemia in relapse: unstable n-ras and flt3 gene...
18225393 - Prognostic significance of the histomorphometric features of bone marrow trephine biops...
21497043 - Plasma von willebrand factor levels are an independent risk factor for adverse events i...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-25
Journal Detail:
Title:  European neurology     Volume:  65     ISSN:  1421-9913     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-3-1     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0150760     Medline TA:  Eur Neurol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  138-143     Citation Subset:  -    
Copyright Information:
Copyright © 2011 S. Karger AG, Basel.
Department of Neurology, Fujita Health University School of Medicine, Toyoake, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  A Method to Estimate Total Entry to Hard Drug Use: The Case of Intravenous Drug Use in Norway.
Next Document:  Cost-Minimisation Analysis in First-Line Treatment of Metastatic Colorectal Cancer in France: XELOX ...