| Neurotrophin Levels in Cerebrospinal Fluid of Adult Patients with Meningitis and Encephalitis. | |
| | |
MedLine Citation:
|
PMID: 21358203 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
|
Background: The data on cerebrospinal fluid (CSF) levels of neurotrophins (NTs) in patients with meningoencephalitis are scarce, especially in adult patients. Methods: We measured CSF levels of NTs such as nerve growth factor (NGF), brain-derived neurotrophic factor, and neurotrophin-3 (NT-3) in adult patients with various meningitis (n = 10) and encephalitis (n = 10) in both acute phase and recovery phase and adult control subjects (n = 21) by the enzyme-linked immunosorbent assay for NTs. Results: Data show that NGF and NT-3 CSF levels were markedly elevated in the patient group in the acute phase compared with non-neurological controls (p < 0.001 and p < 0.05, respectively) and later returned to the levels of controls. Most intriguingly, we only recognized a significant correlation between NGF and NT-3 CSF levels in the patients in the acute phase. Conclusion: Such strong correlation of NGF and NT-3 CSF levels strongly suggests that in adult patients, some common regulatory mechanism(s) might be present among various kinds of NTs to cope with central nervous system infection. |
| | |
Authors:
|
Madoka Kizawa-Ueda; Akihiro Ueda; Naoki Kawamura; Tomomasa Ishikawa; Eri Mutoh; Yu Fukuda; Ryouichi Shiroki; Kiyotaka Hoshinaga; Shinji Ito; Kunihiko Asakura; Tatsuro Mutoh |
Related Documents
:
|
14604283 - Relation of in vitro growth characteristics to cytogenetics and treatment outcome in ac... 20023263 - Diagnosis of myelodysplastic syndrome among a cohort of 119 patients with fanconi anemi... 21078153 - Predictive value of procalcitonin decrease in patients with severe sepsis: a prospectiv... |
Publication Detail:
|
Type: JOURNAL ARTICLE Date: 2011-2-25 |
Journal Detail:
|
Title: European neurology Volume: 65 ISSN: 1421-9913 ISO Abbreviation: - Publication Date: 2011 Feb |
Date Detail:
|
Created Date: 2011-3-1 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 0150760 Medline TA: Eur Neurol Country: - |
Other Details:
|
Languages: ENG Pagination: 138-143 Citation Subset: - |
Copyright Information:
|
Copyright © 2011 S. Karger AG, Basel. |
Affiliation:
|
Department of Neurology, Fujita Health University School of Medicine, Toyoake, Japan. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A Method to Estimate Total Entry to Hard Drug Use: The Case of Intravenous Drug Use in Norway.
Next Document: Cost-Minimisation Analysis in First-Line Treatment of Metastatic Colorectal Cancer in France: XELOX ...