Document Detail


Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway.
MedLine Citation:
PMID:  14614136     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During development and nerve injury, complex interactions between glial cells and neurons are essential for establishing proper nerve function. Neurotrophins play multiple roles in the developing nervous system, including cell survival, growth, and differentiation. Here we show that migration of Schwann cells, isolated from sciatic nerves, is significantly enhanced by neurotrophin 3, but not by nerve growth factor or brain-derived neurotrophic factor. The neurotrophin-3-induced cell migration was also observed in Schwann cells isolated from sciatic nerves of p75NTR-/- mice, indicating that neurotrophin 3 enhances cell migration through TrkC. This effect was blocked by K252a, an inhibitor of the Trk receptor family. Additionally, the neurotrophin-3-induced cell migration depended on Rho GTPases (Rac1 and Cdc42) and c-Jun N-terminal kinase. We obtained the same results with Cos-7 cells expressing TrkC. Taken together, these results suggest that neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase signaling pathway.
Authors:
Junji Yamauchi; Jonah R Chan; Eric M Shooter
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.     Date:  2003-11-12
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  100     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-12-03     Completed Date:  2004-02-02     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  United States    
Other Details:
Languages:  eng     Pagination:  14421-6     Citation Subset:  IM    
Affiliation:
Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305-5125, USA.
Data Bank Information
Bank Name/Acc. No.:
GENBANK/AY336094
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MeSH Terms
Descriptor/Qualifier:
Animals
COS Cells
Cell Movement / drug effects,  physiology
Cells, Cultured
JNK Mitogen-Activated Protein Kinases
Mice
Mice, Knockout
Mitogen-Activated Protein Kinases / metabolism*
Models, Neurological
Molecular Sequence Data
Neurotrophin 3 / pharmacology*
Rats
Receptor, Nerve Growth Factor
Receptor, trkC / genetics,  metabolism*
Receptors, Nerve Growth Factor / deficiency,  genetics,  metabolism
Recombinant Proteins / pharmacology
Schwann Cells / drug effects*,  physiology*
Signal Transduction / drug effects
Transfection
cdc42 GTP-Binding Protein / metabolism
rac1 GTP-Binding Protein / metabolism
Chemical
Reg. No./Substance:
0/Neurotrophin 3; 0/Receptor, Nerve Growth Factor; 0/Receptors, Nerve Growth Factor; 0/Recombinant Proteins; EC 2.7.10.1/Receptor, trkC; EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 3.6.5.2/cdc42 GTP-Binding Protein; EC 3.6.5.2/rac1 GTP-Binding Protein
Comments/Corrections

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