| Neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase pathway. | |
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MedLine Citation:
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PMID: 14614136 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During development and nerve injury, complex interactions between glial cells and neurons are essential for establishing proper nerve function. Neurotrophins play multiple roles in the developing nervous system, including cell survival, growth, and differentiation. Here we show that migration of Schwann cells, isolated from sciatic nerves, is significantly enhanced by neurotrophin 3, but not by nerve growth factor or brain-derived neurotrophic factor. The neurotrophin-3-induced cell migration was also observed in Schwann cells isolated from sciatic nerves of p75NTR-/- mice, indicating that neurotrophin 3 enhances cell migration through TrkC. This effect was blocked by K252a, an inhibitor of the Trk receptor family. Additionally, the neurotrophin-3-induced cell migration depended on Rho GTPases (Rac1 and Cdc42) and c-Jun N-terminal kinase. We obtained the same results with Cos-7 cells expressing TrkC. Taken together, these results suggest that neurotrophin 3 activation of TrkC induces Schwann cell migration through the c-Jun N-terminal kinase signaling pathway. |
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Authors:
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Junji Yamauchi; Jonah R Chan; Eric M Shooter |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. Date: 2003-11-12 |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 100 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 2003 Nov |
Date Detail:
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Created Date: 2003-12-03 Completed Date: 2004-02-02 Revised Date: 2009-11-19 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: United States |
Other Details:
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Languages: eng Pagination: 14421-6 Citation Subset: IM |
Affiliation:
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Department of Neurobiology, Stanford University School of Medicine, Stanford, CA 94305-5125, USA. |
| Data Bank Information | |
Bank Name/Acc. No.:
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GENBANK/AY336094 |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals COS Cells Cell Movement / drug effects, physiology Cells, Cultured JNK Mitogen-Activated Protein Kinases Mice Mice, Knockout Mitogen-Activated Protein Kinases / metabolism* Models, Neurological Molecular Sequence Data Neurotrophin 3 / pharmacology* Rats Receptor, Nerve Growth Factor Receptor, trkC / genetics, metabolism* Receptors, Nerve Growth Factor / deficiency, genetics, metabolism Recombinant Proteins / pharmacology Schwann Cells / drug effects*, physiology* Signal Transduction / drug effects Transfection cdc42 GTP-Binding Protein / metabolism rac1 GTP-Binding Protein / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Neurotrophin 3; 0/Receptor, Nerve Growth Factor; 0/Receptors, Nerve Growth Factor; 0/Recombinant Proteins; EC 2.7.10.1/Receptor, trkC; EC 2.7.11.24/JNK Mitogen-Activated Protein Kinases; EC 2.7.11.24/Mitogen-Activated Protein Kinases; EC 3.6.5.2/cdc42 GTP-Binding Protein; EC 3.6.5.2/rac1 GTP-Binding Protein |
| Comments/Corrections | |
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