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Neurotrophic mediators and corneal wound healing.
MedLine Citation:
PMID:  17131028     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
Neurotrophic keratopathy is an ocular pathological condition that remains difficult to treat. The loss of trigeminal nerve function and corneal sensation that underlies this condition can lead to the development of various disorders of the cornea. Substance P, a sensory neurotransmitter produced by the trigeminal nerve, has been investigated for its effect on corneal epithelial wound healing. Substance P by itself has no direct effect on corneal epithelial migration, but it manifests a synergistic action with insulin-like growth factor-1 (IGF-1) in both epithelial migration in vitro and corneal wound healing in vivo. The minimal amino acid sequences of both substance P and IGF-1 that are required for such effects have been determined. With use of these minimal amino acid sequences, the potential adverse consequences of treatment with the full-length polypeptides may be avoided. The application of eye drops containing a substance P-derived peptide and IGF-1 has proved clinically effective for the treatment of patients with persistent epithelial defects of the cornea.
Authors:
Teruo Nishida
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The ocular surface     Volume:  3     ISSN:  1542-0124     ISO Abbreviation:  Ocul Surf     Publication Date:  2005 Oct 
Date Detail:
Created Date:  2006-11-28     Completed Date:  2007-08-28     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156063     Medline TA:  Ocul Surf     Country:  United States    
Other Details:
Languages:  eng     Pagination:  194-202     Citation Subset:  -    
Affiliation:
Department of Biomolecular Recognition and Ophthalmology, Yamaguchi University School of Medicine, Ube City, Yamaguchi 755-8505, Japan. tnishida@yamaguchi-u.ac.jp
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