Document Detail

Neurotrophic factors and gene therapy in spinal cord injury.
MedLine Citation:
PMID:  11402877     Owner:  NLM     Status:  MEDLINE    
Although it was once thought that the central nervous system (CNS) of mammals was incapable of substantial recovery from injury, it is now clear that the adult CNS remains responsive to various substances that can promote cell survival and stimulate axonal growth. Among these substances are growth factors, including the neurotrophins and cytokines, and growth-supportive cells such as Schwann cells, olfactory ensheathing glia, and stem cells. We review the effects of these substances on promoting axonal growth after spinal cord injury, placing particular emphasis on the genetic delivery of nervous system growth factors to specific sites of injury as a means of promoting axonal growth and, in limited instances, functional recovery.
S Lacroix; M H Tuszynski
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Neurorehabilitation and neural repair     Volume:  14     ISSN:  1545-9683     ISO Abbreviation:  Neurorehabil Neural Repair     Publication Date:  2000  
Date Detail:
Created Date:  2001-06-13     Completed Date:  2001-11-01     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  100892086     Medline TA:  Neurorehabil Neural Repair     Country:  United States    
Other Details:
Languages:  eng     Pagination:  265-75     Citation Subset:  IM    
Department of Neurosciences, University of California, San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0626, USA.
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MeSH Terms
Gene Therapy*
Nerve Growth Factors / therapeutic use*
Nerve Regeneration / drug effects
Spinal Cord Injuries / drug therapy*,  therapy*
Reg. No./Substance:
0/Nerve Growth Factors

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