Document Detail

Neurotrophic factor expression in three infants with Ondine's curse.
MedLine Citation:
PMID:  16243220     Owner:  NLM     Status:  MEDLINE    
This study investigates the expression of some neurotrophic factors (brain-derived neurotrophic factor, glial-derived neurotrophic factor, and nerve growth factor) in the cerebrospinal fluid of infants suffering from idiopathic congenital central hypoventilation syndrome and determines their correlations with this syndrome. Cerebrospinal fluid samples were collected from three infants suffering from idiopathic congenital central hypoventilation syndrome and 15 control subjects with obstructive hydrocephalus to measure the expression of brain-derived neurotrophic factor, glial-derived neurotrophic factor, and nerve growth factor using an immunoenzymatic assay. In the cerebrospinal fluid of patients, analysis of neurotrophic factors expression indicated a reduction, not statistically significant, of brain-derived neurotrophic factor compared with the mean level of the control group (1554 pg/mL, 1509 pg/mL, and 1582 pg/mL respectively, in comparison to 1954 +/- 103 pg/mL), whereas nerve growth factor and glial-derived neurotrophic factor did not undergo significant variations in either group. Neurotrophic factors, namely brain-derived neurotrophic factor, regulate the maturation and differentiation of respiratory neurons. The reduced expression of brain-derived neurotrophic factor in the cerebrospinal fluid samples of infants with Ondine's curse, although not statistically significant, is suggestive of a dysregulation in the brain-derived neurotrophic factor synthesis that could play an important role in the breathing disorders observed in patients with idiopathic congenital central hypoventilation syndrome.
Antonio Chiaretti; Giulia Zorzi; Concezio Di Rocco; Orazio Genovese; Alessia Antonelli; Marco Piastra; Giancarlo Polidori; Luigi Aloe
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Pediatric neurology     Volume:  33     ISSN:  0887-8994     ISO Abbreviation:  Pediatr. Neurol.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-24     Completed Date:  2006-01-13     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8508183     Medline TA:  Pediatr Neurol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  331-6     Citation Subset:  IM    
Pediatric Intensive Care Unit, Catholic University Medical School, Rome, Italy.
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MeSH Terms
Brain-Derived Neurotrophic Factor / cerebrospinal fluid
Glial Cell Line-Derived Neurotrophic Factor / cerebrospinal fluid
Infant, Newborn
Nerve Growth Factor / cerebrospinal fluid
Nerve Growth Factors / cerebrospinal fluid*
Sleep Apnea, Central / cerebrospinal fluid*,  congenital,  physiopathology*
Reg. No./Substance:
0/Brain-Derived Neurotrophic Factor; 0/Glial Cell Line-Derived Neurotrophic Factor; 0/Nerve Growth Factors; 9061-61-4/Nerve Growth Factor

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