| Neurotrophic control of the cell cycle during amphibian limb regeneration. | |
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MedLine Citation:
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PMID: 744947 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is shown here that amputated and denervated limbs of larval axolotls dedifferentiate and a proportion of the cells released undergo DNA synthesis and mitosis. When the limb is denervated prior to amputation fewer cells go through the cell cycle, implying the existence of a pool of trophic factor in the limb. Recent work has demonstrated that denervated blastemal cells accumulate in the G1 phase of the cycle. These results strongly argue against the theory that the trophic factor controls the G2 phase. Rather, it is proposed that this factor regulated either the total number of cells cycling or the rate at which they cycle by varying the length of the G1 phase. |
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Authors:
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M Maden |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of embryology and experimental morphology Volume: 48 ISSN: 0022-0752 ISO Abbreviation: J Embryol Exp Morphol Publication Date: 1978 Dec |
Date Detail:
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Created Date: 1979-05-23 Completed Date: 1979-05-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7906439 Medline TA: J Embryol Exp Morphol Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 169-75 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Ambystoma
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physiology* Amputation Animals DNA / biosynthesis Denervation Forelimb / innervation, physiology* Larva Mitotic Index Peripheral Nerves / physiology* Regeneration* |
| Chemical | |
Reg. No./Substance:
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9007-49-2/DNA |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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