Document Detail


A Neurotrophic Rationale for the Therapy of Neurodegenerative Disorders.
MedLine Citation:
PMID:  19663799     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The concept and rationale for neuroprotection are presented. Several examples of small molecule neurotrophic agents with favourable drug-like and pharmacological properties are shown. Compound efficacy in acute neurodegenerative models (optic nerve axotomy) and chronic neurodegenerative models (glaucoma, age-associated cognitive impairment, Alzheimer's Disease) are evaluated and discussed. Targeting neurotrophin receptors with ligands that activate survival pathways or inhibit death pathways is an alternative worth pursuing.
Authors:
H Uri Saragovi; Edith Hamel; Adriana Di Polo
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2009-10-1
Journal Detail:
Title:  Current Alzheimer research     Volume:  -     ISSN:  1875-5828     ISO Abbreviation:  -     Publication Date:  2009 Oct 
Date Detail:
Created Date:  2009-8-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101208441     Medline TA:  Curr Alzheimer Res     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
The Lady Davis Institute-Jewish General Hospital, 3755 Cote St. Catherine, E-535, Montreal, Quebec, Canada. Uri.Saragovi@mcgill.ca.
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