Document Detail


Neurotransmitters in CSF of idiopathic adult-onset dystonia: reduced 5-HIAA levels as evidence of impaired serotonergic metabolism.
MedLine Citation:
PMID:  9013396     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While several radiological findings point towards the basal ganglia as a possible anatomical site of the lesion in dystonia patients the biochemical basis of the disorder is still unknown. 5-Hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) levels-the respective metabolites of serotonin and dopamine-were measured in lumbar cerebrospinal fluid (lCSF) of 15 patients with idiopathic adult-onset focal dystonia and in lCSF of 11 controls. 100 microliters lCSF were analyzed for 5-HIAA and HVA by reversed-phase HPLC with electrochemical detection. 5-HIAA levels were significantly reduced in dystonia patients (11.4 micrograms/ml) compared to controls (18.4 ng/ml) (p < 0.02). HVA levels in dystonia patients (30.3 ng/ml) were below control values (41.6 ng/ml) but this finding did not reach statistical significance. Decreased lCSF levels of 5-HIAA suggest an impaired serotonin metabolism in patients with idiopathic adult-onset dystonia. This observation may provide a biochemical basis for a more specific pharmacotherapy in dystonia patients.
Authors:
M Naumann; M Götz; K Reiners; K W Lange; P Riederer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neural transmission (Vienna, Austria : 1996)     Volume:  103     ISSN:  0300-9564     ISO Abbreviation:  J Neural Transm     Publication Date:  1996  
Date Detail:
Created Date:  1997-05-12     Completed Date:  1997-05-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9702341     Medline TA:  J Neural Transm     Country:  AUSTRIA    
Other Details:
Languages:  eng     Pagination:  1083-91     Citation Subset:  IM    
Affiliation:
Department of Neurology, University of Würzburg, Federal Republic of Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Aged
Aged, 80 and over
Case-Control Studies
Dopamine / metabolism*
Dystonia / cerebrospinal fluid*
Female
Homovanillic Acid / cerebrospinal fluid*
Humans
Hydroxyindoleacetic Acid / cerebrospinal fluid*
Lumbosacral Region
Male
Middle Aged
Serotonin / metabolism*
Chemical
Reg. No./Substance:
306-08-1/Homovanillic Acid; 50-67-9/Serotonin; 54-16-0/Hydroxyindoleacetic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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