Document Detail

Neurotransmitter-related enzymes in senile dementia of the Alzheimer type.
MedLine Citation:
PMID:  37989     Owner:  NLM     Status:  MEDLINE    
Choline acetyltransferase (ChAT), acetylcholinesterase (AChE) and glutamic acid decarboxylase (GAD) activities were measured in 20 brain regions from autopsied control and senile dementia of the Alzheimer type (SDAT) cases. Large, widespread reductions in the activities of ChAT and AChE were found in tissues from SDAT cases, while GAD activities were reduced in 3 of the 20 regions investigated. AChE activity in cerebrospinal fluid from SDAT cases was similar to that found in samples from non-demented patients.
P Davies
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  171     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1979 Aug 
Date Detail:
Created Date:  1979-10-17     Completed Date:  1979-10-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  319-27     Citation Subset:  IM    
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MeSH Terms
Acetylcholinesterase / metabolism
Alzheimer Disease / enzymology*
Brain / enzymology*
Brain Mapping
Choline O-Acetyltransferase / metabolism
Dementia / enzymology*
Glutamate Decarboxylase / metabolism
Neurotransmitter Agents / metabolism*
Reg. No./Substance:
0/Neurotransmitter Agents; EC O-Acetyltransferase; EC; EC Decarboxylase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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