Document Detail

Neurotransmitter alterations associated with feeding and satiety.
MedLine Citation:
PMID:  3620959     Owner:  NLM     Status:  MEDLINE    
Chronically malnourished rats were sacrificed in a food-deprived state, following eating a small amount of food, or following feeding to satiation. Regional analysis of brain neurotransmitter, neurotransmitter precursor and metabolite concentrations revealed significantly elevated levels of dopamine metabolites in the corpus striatum and nucleus accumbens of the satiated rats. Food-deprived and both refed groups exhibited elevated concentrations of the serotonin metabolite, 5-hydroxyindoleacetic acid, in most brain areas examined. These results suggest increased metabolism of dopamine to be associated with satiety rather than with the act of feeding alone. Increased serotonin metabolism appears to reflect overall nutritional status rather than the onset of satiety.
W T Chance; T Foley-Nelson; J L Nelson; J E Fischer
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  416     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-10-22     Completed Date:  1987-10-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  228-34     Citation Subset:  IM    
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MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Blood Glucose / metabolism
Body Weight
Brain / metabolism*,  physiology
Catecholamines / metabolism*
Feeding Behavior / physiology*
Food Deprivation / physiology
Homovanillic Acid / metabolism
Lactates / blood
Lactic Acid
Rats, Inbred F344
Satiation / physiology*
Satiety Response / physiology*
Serotonin / metabolism*
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Catecholamines; 0/Lactates; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-21-5/Lactic Acid; 50-67-9/Serotonin

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