Document Detail

Neurotransmitter alterations associated with feeding and satiety.
MedLine Citation:
PMID:  3620959     Owner:  NLM     Status:  MEDLINE    
Chronically malnourished rats were sacrificed in a food-deprived state, following eating a small amount of food, or following feeding to satiation. Regional analysis of brain neurotransmitter, neurotransmitter precursor and metabolite concentrations revealed significantly elevated levels of dopamine metabolites in the corpus striatum and nucleus accumbens of the satiated rats. Food-deprived and both refed groups exhibited elevated concentrations of the serotonin metabolite, 5-hydroxyindoleacetic acid, in most brain areas examined. These results suggest increased metabolism of dopamine to be associated with satiety rather than with the act of feeding alone. Increased serotonin metabolism appears to reflect overall nutritional status rather than the onset of satiety.
W T Chance; T Foley-Nelson; J L Nelson; J E Fischer
Related Documents :
2756029 - Wheel running, food intake, and body weight in male rats.
6129699 - The opioid peptide dynorphin, circadian rhythms, and starvation.
1950229 - Serum pattern of thyroxine (t4), 3,3',5-triiodothyronine (t3) and 3,3',5'-triiodothyron...
18377969 - Feeding specific glutamate surge in the rat lateral hypothalamus revealed by low-flow p...
17276349 - Fly foie gras: modeling fatty liver in drosophila.
15748859 - Adaptations to fasting in the american mink (mustela vison): carbohydrate and lipid met...
10629809 - A study on the prevalence of gram-negative bacteria in bulk tank milk.
7979339 - Food aversion induced by area postrema ablation.
3135879 - Abnormal perception of food size in anorexia nervosa.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Brain research     Volume:  416     ISSN:  0006-8993     ISO Abbreviation:  Brain Res.     Publication Date:  1987 Jul 
Date Detail:
Created Date:  1987-10-22     Completed Date:  1987-10-22     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0045503     Medline TA:  Brain Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  228-34     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
3,4-Dihydroxyphenylacetic Acid / metabolism
Blood Glucose / metabolism
Body Weight
Brain / metabolism*,  physiology
Catecholamines / metabolism*
Feeding Behavior / physiology*
Food Deprivation / physiology
Homovanillic Acid / metabolism
Lactates / blood
Lactic Acid
Rats, Inbred F344
Satiation / physiology*
Satiety Response / physiology*
Serotonin / metabolism*
Grant Support
Reg. No./Substance:
0/Blood Glucose; 0/Catecholamines; 0/Lactates; 102-32-9/3,4-Dihydroxyphenylacetic Acid; 306-08-1/Homovanillic Acid; 50-21-5/Lactic Acid; 50-67-9/Serotonin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Effects of acetaldehyde on polymerization of microtubule proteins.
Next Document:  Steroid-independent endogenous opioid peptide suppression of pulsatile luteinizing hormone release b...