Document Detail

Neurotransmitter corelease: mechanism and physiological role.
MedLine Citation:
PMID:  22054239     Owner:  NLM     Status:  MEDLINE    
Neurotransmitter identity is a defining feature of all neurons because it constrains the type of information they convey, but many neurons release multiple transmitters. Although the physiological role for corelease has remained poorly understood, the vesicular uptake of one transmitter can regulate filling with the other by influencing expression of the H(+) electrochemical driving force. In addition, the sorting of vesicular neurotransmitter transporters and other synaptic vesicle proteins into different vesicle pools suggests the potential for distinct modes of release. Corelease thus serves multiple roles in synaptic transmission.
Thomas S Hnasko; Robert H Edwards
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Publication Detail:
Type:  Journal Article; Review     Date:  2011-10-31
Journal Detail:
Title:  Annual review of physiology     Volume:  74     ISSN:  1545-1585     ISO Abbreviation:  Annu. Rev. Physiol.     Publication Date:  2012  
Date Detail:
Created Date:  2012-02-16     Completed Date:  2012-06-12     Revised Date:  2014-09-05    
Medline Journal Info:
Nlm Unique ID:  0370600     Medline TA:  Annu Rev Physiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  225-43     Citation Subset:  IM    
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MeSH Terms
Acetylcholine / metabolism
Anions / metabolism
Biogenic Monoamines / physiology
Cations / metabolism
Chlorides / metabolism,  physiology
Glutamic Acid / metabolism,  physiology
Hydrogen-Ion Concentration
Neurotransmitter Agents / metabolism,  physiology*
Synaptic Transmission / physiology*
Synaptic Vesicles / metabolism,  physiology
Vesicular Neurotransmitter Transport Proteins / metabolism
gamma-Aminobutyric Acid / metabolism
Grant Support
K01 DA026504/DA/NIDA NIH HHS; K01 DA026504-02/DA/NIDA NIH HHS; R01 MH050712/MH/NIMH NIH HHS
Reg. No./Substance:
0/Anions; 0/Biogenic Monoamines; 0/Cations; 0/Chlorides; 0/Neurotransmitter Agents; 0/Protons; 0/Vesicular Neurotransmitter Transport Proteins; 3KX376GY7L/Glutamic Acid; 56-12-2/gamma-Aminobutyric Acid; N9YNS0M02X/Acetylcholine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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