| Neurotransmission-related genetic polymorphisms, negative affectivity traits, and gender predict tobacco abstinence symptoms across 44 days with and without nicotine patch. | |
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MedLine Citation:
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PMID: 19413407 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Genetic and personality trait moderators of tobacco abstinence-symptom trajectories were assessed in a highly controlled study. Based on evidence suggesting their importance in stress reactivity and smoking, moderators studied were serotonin transporter gene (5-HTTLPR) and dopamine D2 receptor gene (DRD2) polymorphisms and personality traits related to negative affect (NA). Smokers were randomly assigned to quit smoking with nicotine or placebo patches. Financial incentives resulted in 80% verified abstinence across the 44-day study. Individuals with 1 or 2 short alleles of 5-HTTLPR (S carriers) experienced larger increases in NA symptoms than did those without a short allele. Nicotine replacement therapy (NRT) alleviated anxiety only in S carriers. NRT reduced NA to a greater extent in DRD2 A1 carriers than in A2A2 individuals during the 1st 2 weeks of treatment (when on the 21-mg patch); however, A1 carriers experienced a renewal of NA symptoms when switched to the 7-mg patch and when off the patch, while A2A2 individuals continued to benefit from NRT. The results suggest that the effects of genotype and treatment may vary across different durations of abstinence, treatment doses, and genotypes. |
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Authors:
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David G Gilbert; Yantao Zuo; Norka E Rabinovich; Hege Riise; Rachel Needham; Jodi I Huggenvik |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Journal of abnormal psychology Volume: 118 ISSN: 1939-1846 ISO Abbreviation: J Abnorm Psychol Publication Date: 2009 May |
Date Detail:
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Created Date: 2009-05-05 Completed Date: 2009-08-11 Revised Date: 2013-06-02 |
Medline Journal Info:
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Nlm Unique ID: 0034461 Medline TA: J Abnorm Psychol Country: United States |
Other Details:
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Languages: eng Pagination: 322-34 Citation Subset: IM |
Affiliation:
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Department of Psychology, Southern Illinois University, Carbondale, IL 62901-6502, USA. dgilbert@siu.edu |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Affect / drug effects Alleles Female Genetic Predisposition to Disease Humans Male Middle Aged Motivation Nicotine / therapeutic use* Nicotinic Agonists / therapeutic use* Polymorphism, Genetic* Receptors, Dopamine D2 / genetics* Risk Assessment Serotonin Plasma Membrane Transport Proteins / genetics* Sex Factors Smoking / drug therapy, genetics*, prevention & control Smoking Cessation / methods*, psychology Synaptic Transmission / genetics Time Factors Treatment Outcome Young Adult |
| Grant Support | |
ID/Acronym/Agency:
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R01 DA012289/DA/NIDA NIH HHS; R01 DA012289-02/DA/NIDA NIH HHS; R01 DA12289/DA/NIDA NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Nicotinic Agonists; 0/Receptors, Dopamine D2; 0/Serotonin Plasma Membrane Transport Proteins; 54-11-5/Nicotine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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