| Neurotoxicity of long-term low-level exposure to carbon disulphide: results of questionnaire, clinical neurological examination and neuropsychological testing. | |
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MedLine Citation:
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PMID: 9192217 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: Carbon disulphide (CS2) is highly neurotoxic. There is ample evidence of damage to the peripheral and central nervous system. The air concentration at which such adverse effects can first be observed is presently a subject of controversy. METHODS: In a cross-sectional study of CS2-exposed workers from the viscose industry and healthy controls, data on neurological complaints, basic laboratory diagnosis, clinical neurological examination and neuropsychological testing were evaluated. Data were from 222 workers in the viscose industry exposed to CS2 and 191 employees from the same factory with similar physical and psychological stress factors but without occupational contact with neurotoxic substances. Multiple linear or multiple logistic regression analysis was used to check for statistical differences. RESULTS: The median of the CS2-measurements using personal air sampling was below the current maximum concentration permissible (MAK value) in Germany (10 ppm) in all departments. The threshold limit value was, however, exceeded in almost 10% of the persons investigated. Exposure fluctuated between < 0.2 and 65.7 ppm (median of all departments was 4.02 ppm). As a parameter of internal exposure, CS2-metabolite 2-thio-1,3-thiazolidine-4-carboxylic acid (TTCA) concentrations in the urine of the exposed persons were between < 0.16 and 10.9 mg/g creatinine (median 1.43 mg/g). CONCLUSIONS: Neither an increase in subjective complaints nor an increase in pathological findings in clinical-neurological and neuropsychological examination could be found in persons exposed to CS2 at the exposure levels described. |
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Authors:
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F Reinhardt; H Drexler; A Bickel; D Claus; J Angerer; K Ulm; G Lehnert; B Neundörfer |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International archives of occupational and environmental health Volume: 69 ISSN: 0340-0131 ISO Abbreviation: Int Arch Occup Environ Health Publication Date: 1997 |
Date Detail:
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Created Date: 1997-08-06 Completed Date: 1997-08-06 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7512134 Medline TA: Int Arch Occup Environ Health Country: GERMANY |
Other Details:
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Languages: eng Pagination: 332-8 Citation Subset: IM |
Affiliation:
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Department of Neurology, University of Erlangen-Nuremberg, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Air Pollutants, Occupational / adverse effects*, metabolism Carbon Disulfide / adverse effects*, metabolism Cohort Studies Cross-Sectional Studies Humans Male Middle Aged Nervous System Diseases / chemically induced*, urine Neurologic Examination Neuropsychological Tests* Occupational Diseases / chemically induced, urine Occupational Exposure / analysis Questionnaires Thiazoles / urine Thiazolidines |
| Chemical | |
Reg. No./Substance:
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0/Air Pollutants, Occupational; 0/Thiazoles; 0/Thiazolidines; 20933-67-9/2-thioxo-4-thiazolidinecarboxylic acid; 75-15-0/Carbon Disulfide |
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