Document Detail


Neurotoxicity of levodopa on catecholamine-rich neurons.
MedLine Citation:
PMID:  1557063     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The human neuroblastoma cells NB69 are a catecholamine-rich cell line with pharmacological properties similar to dopamine neurons. This cell line was used to study the neurotoxicity of levodopa on catecholamine neurons. Levodopa, at 50 x 10(-6) M or higher concentrations, produced a dose- and time-dependent reduction in the number of live cells, [3H]thymidine uptake, levels of protein and DNA, and an enhancement of the quinone formation. This is a specific effect of levodopa since it did not happen in NB69 cells incubated with equimolar concentrations of leucine and tryptophan. Treatment with deprenyl, an inhibitor of monoamine oxidase type B, partially prevented levodopa neurotoxicity, suggesting that the mechanism of toxicity was, at least in part, related to an increase in the metabolism of dopamine catalyzed by monoamine oxidase.
Authors:
M A Mena; B Pardo; M J Casarejos; S Fahn; J García de Yébenes
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Movement disorders : official journal of the Movement Disorder Society     Volume:  7     ISSN:  0885-3185     ISO Abbreviation:  Mov. Disord.     Publication Date:  1992  
Date Detail:
Created Date:  1992-05-04     Completed Date:  1992-05-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8610688     Medline TA:  Mov Disord     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  23-31     Citation Subset:  IM    
Affiliation:
Departamento de Investigación, Centro Ramón y Cajal, Madrid, Spain.
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MeSH Terms
Descriptor/Qualifier:
Catecholamines / physiology*
Cell Line
Cell Survival / drug effects*
Dopamine / physiology
Dose-Response Relationship, Drug
Humans
Levodopa / pharmacokinetics,  toxicity*
Neuroblastoma
Neurons / drug effects*,  physiology
Selegiline / pharmacology
Chemical
Reg. No./Substance:
0/Catecholamines; 0/Levodopa; 14611-51-9/Selegiline

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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