Document Detail


Neurotoxicity and lethality of toxic extracts from Atlantic coast shellfish.
MedLine Citation:
PMID:  2748879     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
1. HCl-extract of poisonous shellfish was injected i.p. into Swiss-Webster mice. 2. Behavioral effects (sluggishness, scratching, huddling, clonic convulsions, respiratory distress and mortality) were noted. 3. Infant mice were more sensitive than were the adults to XTRT toxicity. Estimated LD50 values were; adult: 34.8 ml/kg i.p., infant: 9.6 ml/kg i.p. 4. The mouse model of shellfish-toxicity offers the advantages of a degree of similarity with the human clinical situation and a rapid time course for screening antagonists against shellfish poisoning.
Authors:
R Bose; G B Glavin; C Pinsky
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Progress in neuro-psychopharmacology & biological psychiatry     Volume:  13     ISSN:  0278-5846     ISO Abbreviation:  Prog. Neuropsychopharmacol. Biol. Psychiatry     Publication Date:  1989  
Date Detail:
Created Date:  1989-08-21     Completed Date:  1989-08-21     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8211617     Medline TA:  Prog Neuropsychopharmacol Biol Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  559-62     Citation Subset:  IM    
Affiliation:
Department of Pharmacology, University of Manitoba, Winnipeg, Canada.
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MeSH Terms
Descriptor/Qualifier:
Aging
Animals
Behavior, Animal / drug effects*
Dose-Response Relationship, Drug
Male
Mice
Neurotoxins / toxicity*
Shellfish / toxicity*
Tissue Extracts / toxicity
Chemical
Reg. No./Substance:
0/Neurotoxins; 0/Tissue Extracts

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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