Document Detail


Neurotoxicity of general anesthetics in childhood : Does anesthesia leave its mark on premature babies, newborns and infants?
MedLine Citation:
PMID:  23392218     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Many animal experiments have shown that anesthetics can have a neurotoxic effect on immature brains because they induce apoptosis and influence neurogenesis and synaptogenesis. In animal experiments this has substantial implications for the neurocognitive functions of animals in later life. Whether these results of animal experiments can be transferred to humans is currently the subject of intensive research. In several retrospective studies no clear association between anesthesia in premature babies, newborns or infants and the occurrence of learning disorders or behavioral problems could be found. The prospective studies GAS and PANDA are designed to obtain a deeper insight and if possible to clarify this problem. Because of the high relevance of this topic and in order to achieve more clarity for this problem when dealing with parents, the scientific working group for neuroanesthesia and pediatric anesthesia of the German Society for Anesthesiology and Intensive Care Medicine (DGAI) has formulated a position document on the basis of currently available data.
Authors:
B Sinner; K Becke; K Engelhard
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-2-9
Journal Detail:
Title:  Der Anaesthesist     Volume:  -     ISSN:  1432-055X     ISO Abbreviation:  Anaesthesist     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-2-8     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370525     Medline TA:  Anaesthesist     Country:  -    
Other Details:
Languages:  GER     Pagination:  -     Citation Subset:  -    
Affiliation:
Klinik für Anästhesiologie, Universitätsklinikum Regensburg, Franz-Josef-Strauss Allee 11, 93053, Regensburg, Deutschland, barbara.sinner@klinik.uni-regensburg.de.
Vernacular Title:
Neurotoxizität von Allgemeinanästhetika im Kindesalter : Hinterlässt Narkose Spuren beim Früh-, Neugeborenen und Kleinkind?
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