| Neurotoxic insecticides inhibit GABA-dependent chloride uptake by mouse brain vesicles. | |
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MedLine Citation:
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PMID: 3000377 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The neurotoxic insecticides endrin, dieldrin, aldrin, lindane (gamma-1,2,3,4,5,6-hexachlorocyclohexane) and deltamethrin inhibited gamma-aminobutyric acid-dependent 36Cl- uptake by mouse brain vesicles. Of the insecticides examined, the chlorinated cyclodienes endrin and dieldrin were the most potent, producing 50% inhibition at 2.8 and 13.9 microM, respectively. Lindane and deltamethrin were less effective, and with deltamethrin the effect was incompletely stereospecific. These results demonstrate the disruption of gamma-aminobutyric acid receptor-chloride ionophore function in mammalian brain by neurotoxic insecticides and provide evidence that this complex is the principal site of cyclodiene action. |
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Authors:
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J R Bloomquist; D M Soderlund |
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Publication Detail:
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Type: In Vitro; Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 133 ISSN: 0006-291X ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 1985 Nov |
Date Detail:
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Created Date: 1986-01-15 Completed Date: 1986-01-15 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 37-43 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bicyclo Compounds / metabolism, pharmacology Bicyclo Compounds, Heterocyclic* Brain / drug effects, metabolism* Chlorides / metabolism* Insecticides / toxicity* Male Mice Mice, Inbred ICR Picrotoxin / pharmacology Receptors, GABA-A / drug effects gamma-Aminobutyric Acid / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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ES02160/ES/NIEHS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Bicyclo Compounds; 0/Bicyclo Compounds, Heterocyclic; 0/Chlorides; 0/Insecticides; 0/Receptors, GABA-A; 124-87-8/Picrotoxin; 56-12-2/gamma-Aminobutyric Acid; 70636-86-1/tert-butylbicyclophosphorothionate |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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