| Neurotoxic effects of organophosphorus insecticides. An intermediate syndrome. | |
MedLine Citation:
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PMID: 3029588 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Acute neurotoxic effects during the cholinergic phase of organophosphorus insecticide poisoning and delayed neurotoxic effects appearing two to three weeks later are well recognized. We observed 10 patients who had paralysis of proximal limb muscles, neck flexors, motor cranial nerves, and respiratory muscles 24 to 96 hours after poisoning, after a well-defined cholinergic phase. The compounds involved were fenthion, monocrotophos, dimethoate, and methamidophos. Four patients urgently required ventilatory support. The paralytic symptoms lasted up to 18 days. A delayed polyneuropathy later developed in one patient. Three patients died. Electromyographic studies showed fade on tetanic stimulation, absence of fade on low-frequency stimulation, and absence of post-tetanic facilitation, suggestive of a postsynaptic defect. This neuromuscular junctional defect may have been the predominant cause of the paralytic symptoms, with neural and central components contributing to various degrees. Our patients appeared to have a distinct clinical entity (a so-called intermediate syndrome) that developed after the acute cholinergic crisis and before the expected onset of the delayed neuropathy. |
Authors:
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N Senanayake; L Karalliedde |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The New England journal of medicine Volume: 316 ISSN: 0028-4793 ISO Abbreviation: N. Engl. J. Med. Publication Date: 1987 Mar |
Date Detail:
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Created Date: 1987-04-07 Completed Date: 1987-04-07 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0255562 Medline TA: N Engl J Med Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 761-3 Citation Subset: AIM; IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Dimethoate / poisoning Electromyography Female Fenthion / poisoning Humans Insecticides / poisoning* Male Middle Aged Monocrotophos / poisoning Neuromuscular Junction / drug effects Organothiophosphorus Compounds / poisoning Peripheral Nervous System Diseases / chemically induced* Respiratory Paralysis / chemically induced Synaptic Transmission / drug effects Time Factors |
| Chemical | |
Reg. No./Substance:
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0/Insecticides; 0/Organothiophosphorus Compounds; 10265-92-6/methamidophos; 55-38-9/Fenthion; 60-51-5/Dimethoate; 6923-22-4/Monocrotophos |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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