Document Detail


Neurotoxic effects of 25mg/kg/bodyweight of artemether on the histology of the trapezoid nuclei and behavioural functions in adult male Wistar rats.
MedLine Citation:
PMID:  19026440     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study investigated the effects of the administration of 25mg/kg/bodyweight of artemether for a period of 7 days on the trapezoid nuclei and behavioural functions in male Wistar rats. This was to establish the neurotoxic potential of artemether as an antimalarial drug. All rats showed normal morphological appearances at the completion of the experimental procedure. Statistical analyses showed no significant differences between the average brain weight of the control group and the experimental group. The assessment of brainstem nuclei showed patchychromatic appearance of neurons of the trapezoid nuclei in the experimental group as against the normal vesicular appearance of neurons of the trapezoid nuclei in the control group. The density of damaged trapezoid nuclei was significantly higher in the experimental group than in the control group. The rats in the control group displayed normal balance and coordination, while rats in the experimental group showed abnormalities in balance and coordination. This study observed that administration of 25mg/kg/bodyweight of artemether for a period of 7 days had neurotoxic effects on the trapezoid nuclei of Wistar rats.
Authors:
Abdulazeez Adelaja Akinlolu; Mathew Temitayo Shokunbi
Publication Detail:
Type:  Journal Article     Date:  2008-11-20
Journal Detail:
Title:  Acta histochemica     Volume:  112     ISSN:  1618-0372     ISO Abbreviation:  Acta Histochem.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-02-09     Completed Date:  2010-08-06     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0370320     Medline TA:  Acta Histochem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  193-8     Citation Subset:  IM    
Copyright Information:
Copyright 2008 Elsevier GmbH. All rights reserved.
Affiliation:
Department of Anatomy, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Remo Campus, Ogun State, Nigeria. a3laja@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimalarials* / administration & dosage,  adverse effects
Artemisinins* / administration & dosage,  adverse effects
Drug Administration Schedule
Gait / drug effects*,  physiology
Injections, Intramuscular
Male
Neurons / drug effects,  pathology*
Pons / drug effects,  pathology*
Postural Balance / drug effects*,  physiology
Rats
Rats, Wistar
Chemical
Reg. No./Substance:
0/Antimalarials; 0/Artemisinins; 0/artemether

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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