Document Detail

Neuroticism, extraversion, and mortality in the UK Health and Lifestyle Survey: a 21-year prospective cohort study.
MedLine Citation:
PMID:  17991814     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To examine the influence of neuroticism and extraversion on all-cause and cause-specific mortality over 21 years after controlling for risk factors.
METHODS: Participants were members of the Health and Lifestyle Survey, a British nationwide sample survey of 9003 adults. At baseline (1984 to 1985), individuals completed a sociodemographic and health questionnaire, underwent physical health examination, and completed the Eysenck Personality Inventory. Mortality was assessed for 21 years after baseline. A total of 5424 individuals had complete data.
RESULTS: After controlling for age and gender, 1-standard deviation (SD) increase in neuroticism was related to 9% (hazard ratio (HR) = 1.09; 95% Confidence Interval (CI) = 1.03-1.16) increased risk of mortality from all causes. The association was nonsignificant (HR = 1.05; 95% CI = 0.99-1.11) after additionally controlling for occupational social class, education, smoking, alcohol consumption, physical activity, and health. There was 12% (HR = 1.12; 95% CI = 1.03-1.21) increased risk of death from cardiovascular disease associated with 1-SD increase in neuroticism. This was still significant after adjustment. When the sample was divided into 40- to 59-year-olds and those >or=60 years, neuroticism remained a significant risk for all-cause mortality and cardiovascular disease mortality; associations were nonsignificant after controlling for all covariates. Neuroticism was not associated with deaths from stroke, respiratory disease, lung cancer, or other cancers. Extraversion was protective of death from respiratory disease (HR = 0.84; 95% CI = 0.70- 1.00).
CONCLUSIONS: After controlling for several risk factors, high neuroticism was significantly related to risk of death from cardiovascular disease. The effects of neuroticism on death from cardiovascular disease may be mediated by sociodemographic, health behavior, and physiological factors.
Beverly A Shipley; Alexander Weiss; Geoff Der; Michelle D Taylor; Ian J Deary
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-11-08
Journal Detail:
Title:  Psychosomatic medicine     Volume:  69     ISSN:  1534-7796     ISO Abbreviation:  Psychosom Med     Publication Date:  2007 Dec 
Date Detail:
Created Date:  2007-11-27     Completed Date:  2007-12-17     Revised Date:  2014-02-19    
Medline Journal Info:
Nlm Unique ID:  0376505     Medline TA:  Psychosom Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  923-31     Citation Subset:  IM    
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MeSH Terms
Cardiovascular Diseases / mortality*,  psychology
Cause of Death*
Cohort Studies
Extraversion (Psychology)*
Great Britain
Health Behavior*
Health Surveys
Life Style*
Longitudinal Studies
Middle Aged
Neurotic Disorders / complications*,  mortality,  psychology
Personality Inventory
Proportional Hazards Models
Prospective Studies
Psychophysiologic Disorders / mortality*,  psychology
Risk Factors
Survival Analysis
Grant Support
G106/1258//Medical Research Council; MC_U130059821//Medical Research Council
Erratum In:
Psychosom Med. 2008 Feb;70(2):265

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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